Childhood asthma is a highly heterogeneous chronic respiratory disease, and its onset and progression are intricately linked to genetic susceptibility, environmental exposure, immune development, and the establishment of the early-life microbiome. In r…
BackgroundLocal expression of complement components in the kidney has been reported sporadically in both diseased and normal kidneys. This study aimed to comprehensively characterize the expression of complement components in human glomerular mesangial…
BackgroundApproximately 10%–30% patients with biopsy-proven membranous nephropathy (MN) are seronegative for anti-phospholipase A2 receptor antibody (PLA2R-Ab). Only ~5% are truly non-PLA2R MN and are associated with alternative antigens (e.g., THSD7A)…
BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by severe synovial inflammation, joint deformities, and progressive tissue destruction. Celastrol (Cel), a natural triterpenoid with anti-inflammatory and antioxidant ac…
Mexico has been one of the countries most affected by the COVID-19 pandemic. Several factors can influence the susceptibility to SARS-CoV-2 infection, particularly highly polymorphic genes in the HLA system. Therefore, this pilot study analyzed the ass…
BackgroundCKD represents a substantial worldwide health challenge, defined by the gradual development of tubulointerstitial fibrosis and reduced renal performance. Autoimmune-mediated factors are central to this pathological process, yet early diagnost…
BackgroundPreclinical transplantation models largely rely on macroscopic or terminal assessments of graft fate, limiting longitudinal evaluation of immune rejection and tolerance induction. Reporter proteins such as enhanced green fluorescent protein (…
