Anti-GQ1b antibody syndromes span a clinical continuum from peripheral Guillain-Barré syndrome (GBS) to central Bickerstaff brainstem encephalitis (BBE), but reliable biomarkers of central nervous system (CNS) involvement that could guide treatment int…
IntroductionSingle-cell RNA sequencing (scRNA-seq) has opened unprecedented possibilities to explore the complexity of the immune system. However, existing methods primarily rely on expression-based clustering analysis, which lacks mechanistic explanat…
Palisaded neutrophilic granulomatous dermatitis (PNGD) is an uncommon reactive granulomatous dermatosis frequently associated with rheumatoid arthritis (RA). Histopathologically, PNGD is characterized by neutrophilic infiltrates, degenerated collagen b…
BackgroundPost-cyclophosphamide (PTCy)-based GVHD prophylaxis has shown significant success in haploidentical transplants. The potential of PTCy in adult umbilical blood transplantation (UCBT) remains unclear due to concerns about engraftment, given th…
Despite breakthrough advancements in cancer immunotherapy, significant inter-individual heterogeneity in clinical outcomes persists, bringing the regulatory roles of intrinsic host biological variables into sharp focus. Accumulating fundamental and cli…
BackgroundLower peripheral lymphocyte counts are associated with mortality in sepsis, but evidence across related adaptive immune-cell compartments has not been systematically quantified.MethodsNine databases were searched from inception through 7 Augu…
Chimeric antigen receptor (CAR) T-cell therapy has revolutionised cancer gene therapy, yet its expansion into solid tumours is hindered by a critical vulnerability: the autonomous, “always-on” nature of conventional CAR constructs. This unregulated act…
BackgroundEndometriosis is frequently associated with impaired fertility. Metabolic abnormalities and dyslipidemia may be relevant to reproductive dysfunction among women with endometriosis; however, their associations with subsequent reproductive outc…
BackgroundLung cancer remains one of the most common and lethal malignancies worldwide. The advent of immune checkpoint inhibitors (ICIs) has substantially improved survival outcomes in patients with advanced disease; nevertheless, a considerable propo…
The interplay between neutrophils and macrophages is central to inflammatory regulation, yet how macrophage polarization governs the homeostasis of neutrophil extracellular traps (NETs) remains poorly understood. Here, we show that the macrophage polar…
