Interactions between neutrophil extracellular traps (NETs) and macrophages play a critical role in the initiation and progression of inflammatory diseases. NETs regulate macrophage polarization and function by releasing components such as DNA, histones…
IntroductionEndometrial receptivity is essential for implantation in both natural and ART cycles, yet the cellular and molecular environment of the endometrium during this window remains poorly characterized. While cytokines affecting implantation have…
BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and gut microbiota dysbiosis. Gnaphalium hypoleucum DC. total flavonoids (GHTFs) exhibit anti-inflammatory and immunomodulatory properties.Methods and re…
Sepsis is a life-threatening organ failure syndrome triggered by dysregulated host responses to infection. During disease progression, macrophages drive initial hyperinflammatory responses and critically regulate the subsequent immunosuppressive phase….
Systemic amyloidosis is a protein folding disorder characterized by the extracellular deposition of protein fibrils in tissues and vital organs, leading to dysfunction and mortality. While there are monoclonal antibody-based therapies that promote cell…
ObjectiveRecurrent spontaneous abortion (RSA) affects 0.5%–2.5% of fertile couples and arises from complex, interacting thrombotic, immune, coagulation, endocrine–metabolic, and demographic factors. However, current early risk stratification in routine…
Allergic conjunctivitis (AC) is an inflammatory ocular condition triggered by allergens like pollen. Although general allergic mechanisms are well characterized, the immune specificity of the ocular mucosa remains unclear. This study investigates immun…
IntroductionPregnancy requires coordinated immunometabolic adaptations that allow maternal immune tolerance while preserving tissue remodeling and host defense. Circulating monocytes contribute critically to these processes, yet how gestation shapes th…
BackgroundIschemic stroke, a predominant cause of global mortality and disability, involves complex pathophysiological processes where neuroinflammation and pyroptosis play a crucial role. We aimed to investigate the role of the brain’s major water cha…
Severe asthma remains a major unmet clinical challenge, largely due to corticosteroid hyporesponsiveness in a subset of patients. Despite high-dose inhaled or systemic corticosteroids and targeted biologics, chronic airway inflammation often persists, …
