IntroductionCutaneous leishmaniasis (CL) caused by Leishmania braziliensis displays a wide spectrum of clinical manifestations characterized by an inflammatory Th1 response that leads to the development of skin lesions. In endemic areas of L. brazilien…
BackgroundAcute myocardial infarction (AMI) incidence increases with population aging, alongside heightened cellular senescence; however, clinically useful senescence-related genes (SRGs) for AMI remain poorly defined. This study aimed to identify AMI-…
BackgroundAtopic dermatitis (AD) is a common chronic skin inflammation, which affects 15-20% of children worldwide. Gut microbiota and its metabolites are crucial modulators of the “gut-skin axis” in atopic dermatogenesis. However, systematic investiga…
BackgroundOsteoarthritis (OA) is a common degenerative disease characterized by the deterioration of articular cartilage, affecting approximately 240 million people worldwide. Low-grade inflammation—particularly the imbalance in macrophage polarization…
Background and objectivesNatalizumab (NTZ) is a high-efficacy therapy for relapsing-remitting multiple sclerosis (RRMS) that blocks peripheral immune cell migration into the central nervous system. While short-term NTZ treatment reduces cerebrospinal f…
IntroductionABO-incompatible kidney transplantation (ABOi-KT) expands the donor pool, yet baseline anti-ABO isoagglutinin titres ≥ 1:512 remain challenging and practice is highly variable. We surveyed the German transplant centres to capture current ma…
Dendritic cells (DC) play a central role in host immunity as they carry environmental cues from sites of infection to the lymphatics, where they subsequently direct appropriate adaptive immune responses. Importantly, this process is exploited by pathog…
Neuroendocrine breast cancer (NEBC) is an exceedingly rare malignant tumor, with primary triple-negative NEBC representing an even rarer and more aggressive subtype lacking standardized treatment guidelines. Although pembrolizumab combined with chemoth…
BackgroundResearch on the role of immune dysregulation in multidrug-resistant organism (MDRO) infections among patients with ventilator-associated pneumonia (VAP) remains limited, and there is a lack of reliable immunological indicators for early ident…
IntroductionRecombinant adeno-associated virus (rAAV)-mediated delivery of neutralizing antibodies is a promising strategy for rapid and durable prophylaxis against SARS-CoV-2.MethodsWe evaluated the long-term expression, pharmacokinetics, immunogenici…
