IntroductionOnly a subset of epithelial cells can initiate progressive lung adenocarcinoma (LUAD), yet the founder cell states that confer this competence remain poorly defined.MethodsWe established a barcoded KrasG12D, Trp53 loss mouse LUAD organoid m…
Hepatocellular carcinoma (HCC) commonly develops in the context of chronic liver injury and fibrosis, and its immune evasion and therapeutic resistance are shaped not only by tumor-intrinsic factors but also by persistent interactions between the tumor…
BackgroundThe tumor microenvironment (TME) of gastric adenocarcinoma is exceptionally heterogeneous, and epithelial-mesenchymal transition (EMT) is a central mechanism promoting local invasion and metastatic spread. Even so, how EMT-programmed cells ar…
Programmed death 1 (PD-1) inhibitors have transformed the treatment of advanced non-small cell lung cancer (NSCLC), but durable responses remain limited to a subset of patients. Conventional biomarkers, including PD-L1 expression and tumor mutational b…
Atopic dermatitis is a chronic inflammatory skin disease characterized by type 2 immune responses and severe itching; however, the molecular mechanisms linking lipid metabolism to epithelial–immune signaling remain incompletely understood. Herein, we s…
BackgroundAcute myeloid leukemia (AML) shows substantial biological and clinical heterogeneity that extends beyond leukemia-intrinsic genetic alterations. MRC1, which encodes the myeloid receptor CD206, has been linked to monocytic differentiation and …
Gestational diabetes mellitus (GDM) is a prevalent metabolic complication of pregnancy with rising global incidence. Its increasing prevalence parallels the rising rates of pre-pregnancy obesity worldwide. While physiological insulin resistance is a no…
IntroductionELF4 is an ETS family transcription factor involved in immune regulation, including antiviral responses and inflammatory signaling. Germline loss-of-function variants in ELF4 cause deficiency in ELF4, X-linked (DEX), a disorder characterize…
BackgroundThis study evaluates the quality of study design, potential biases, and evidence strength for childhood risk factors associated with allergic rhinitis (AR), while summarizing the key identified factors.MethodsThe protocol for this review was …
Cervical cancer remains a leading cause of cancer death in women, and outcomes in recurrent or metastatic disease remain poor despite chemoradiation and bevacizumab. The HPV-driven biology that defines the disease—viral E6/E7 oncoproteins, an inflamed …
