BackgroundMacrophages play an indispensable role in the pathogenesis of aortic dissection (AD). However, the underlying molecular and cellular mechanisms remain incompletely understood.MethodsWe integrated six publicly available single-cell RNA sequenc…
Head and neck squamous cell carcinoma (HNSCC) remains difficult to treat, particularly in patients with HPV-negative disease. These patients often get diagnosed too late, their cancer doesn’t respond well to treatment, and they don’t live as long. Onco…
BackgroundHuman papillomavirus (HPV) drives both malignant and benign tumours. Current prophylactic vaccines are type-restricted, not optimised for T-cell induction, and lack therapeutic efficacy. Although T-cells are critical for both preventing and c…
Threatened abortion (TA), vaginal bleeding before 20 weeks in a viable pregnancy, affects 20-25% of early pregnancies. Its unpredictable nature is a major clinical challenge. Current diagnostics (β-hCG and ultrasound) are retrospective and fail to reve…
IntroductionColorectal cancer liver metastasis (CRLM) develops in a hepatic niche where tumor cells encounter organ‑specific microbial, metabolic, and immune constraints. The role of intratumoral bacteria in this metastatic ecosystem remains incomplete…
Traumatic brain injury (TBI) triggers a complex cascade of immune responses that extend beyond the central nervous system and contribute to secondary neuropathology. Increasing evidence implicates T helper 17 cells (Th17) and their signature cytokine i…
BackgroundUlcerative colitis (UC) is a chronic relapsing inflammatory bowel disease characterized by mucosal immune imbalance, epithelial barrier disruption, and intestinal dysbiosis. Curcumol (CUR) possesses anti-inflammatory and immunomodulatory acti…
Intracerebral hemorrhage (ICH) is a life-threatening subtype of stroke characterized by the acute accumulation of blood within the brain parenchyma and progressive secondary brain injury. After ICH, dysregulated neuroinflammation drives a cascade of se…
ObjectiveTo investigate the association between admission C-reactive protein (CRP) levels and complicated or high-risk presentations in acute Stanford type B aortic dissection (TBAD) and to evaluate the potential value of CRP as a simple, inexpensive, …
Articular cartilage is characterized by an avascular structure and limited intrinsic regenerative capacity. The most prevalent pathological conditions that lead to cartilage damage are osteoarthritis (OA) and rheumatoid arthritis (RA). In recent decade…
