Articular cartilage is characterized by an avascular structure and limited intrinsic regenerative capacity. The most prevalent pathological conditions that lead to cartilage damage are osteoarthritis (OA) and rheumatoid arthritis (RA). In recent decade…
BackgroundPancreatic cancer (PC) is a fatal malignancy, with glycolysis and T cells playing crucial roles in its pathogenesis. This study explored prognosis-related genes in glycolysis and T cells in PC using bioinformatics methods.MethodsWe first quan…
Immunometabolic dysregulation orchestrating bidirectional peripheral–central inflammatory crosstalk has been increasingly recognized as a contributor to Alzheimer’s disease (AD) pathogenesis, challenging the conventional view of AD as an isolated centr…
Tuberculosis (TB) remains a major global health burden, yet the mechanisms by which Mycobacterium tuberculosis (Mtb) adapts to host environments to drive disease pathology are incompletely defined. A key limitation has been reliance on axenic culture s…
Neutrophil Extracellular Traps (NETs) are web-like structures composed of DNA fibers, histones, and granular proteins released by the neutrophils activated upon various stimuli. Recognized as a host immune defense mechanism, NETs also play a significan…
γδ T cells have raised interest as effector cells in cancer immunotherapy, due to their broad and HLA-independent reactivity towards multiple tumor entities. Despite promising ongoing clinical studies, there is a need to improve the effector function a…
Granulomatous lobular mastitis (GLM) is a chronic inflammatory breast disease characterized by granuloma formation, abscesses, fat necrosis, and recurrent tissue injury. This study investigated whether Tuoli Tounong decoction (TTN) promotes lesion reso…
IntroductionAlthough the role of cancer-associated fibroblasts (CAFs) in cancer progression is increasingly recognized, their spatial dynamics and interactions with immune cells remain poorly understood.MethodsHere, we present a computational framework…
Infantile-onset Multisystem Autoimmune Disease type 1(ADMIO, 1) is a rare hereditary autoimmune disorder primarily caused by STAT3 gain-of-function (GOF) mutations. This article presents a case of ADMIO type 1 resulting from a de novo STAT3 GOF mutatio…
Although daratumumab has been reported to significantly improve the prognosis of multiple myeloma (MM), its efficacy in patients with cytogenetically high-risk MM (HRMM) remains unclear. This meta-analysis aims to evaluate the effect of daratumumab on …
