Traditional treatments for lung cancer include surgery, radiotherapy, chemotherapy, and targeted therapies (such as Erlotinib, Gefitinib, and Crizotinib), as well as immunotherapy (such as Nivolumab and Pembrolizumab). However, these approaches face ch…
IntroductionIn multiple myeloma (MM), the immune system is disrupted, partly due to tumor-modified bone marrow mesenchymal stromal cells (BM-MSCs). These MSCs show altered glycosylation, including increased sialylation, which may promote immune evasion…
Severe asthma is characterized by persistent airway inflammation, irreversible airway remodeling, and reduced responsiveness to glucocorticoids. Subepithelial fibrosis, a major determinant of progressive lung function decline, remains mechanistically u…
Effective risk stratification is vital for donor selection and treatment strategies in allogeneic hematopoietic stem cell transplantation (HSCT). We developed a prediction model for mid- to long-term outcomes after HSCT using a stacked ensemble model (…
As the largest organ of the human body, the skin is essential for maintaining systemic homeostasis; however, it remains highly susceptible to injury and wound formation, posing a significant clinical and economic burden. Wound healing is a complex, tig…
ObjectiveThis study aimed to investigate whether hippocampal texture asymmetry features extracted from PET could effectively differentiate anti-LGI1 encephalitis from anti-GABABR encephalitis based on a hippocampal laterality radiomics (HLR) model.Meth…
IntroductionNatural killer cell alloreactivity contributes to the graft-versus-leukemia (GVL) effect of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). However, its importance remains controversial across studies.MethodsIn this ret…
Protein palmitoylation has emerged as a central post-translational mechanism governing protein localization, stability, and signal transduction. In hematological malignancies, this dynamic modification lies at the intersection of lipid metabolic reprog…
BackgroundAutoimmune encephalitis (AE) is clinically heterogeneous, but whether relapse predictors and structural correlates of disability differ by antibody status remains unclear. We aimed to identify serostatus-specific predictors of relapse and det…
Gastrointestinal cancers frequently develop immune exclusion and therapeutic resistance, yet these phenotypes are often described separately. Cancer-associated fibroblasts (CAFs) are key stromal architects of immune-excluded tumor microenvironments, an…
