RationaleChronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. As lung transplantation is the only curative option and current therapies are largely based on managing clinical symptoms, novel treatments are urgentl…
Gastric cancer (GC) is characterized by marked heterogeneity and frequent resistance to chemotherapy and immunotherapy. Exosomes mediate intercellular communication between tumor, stromal, and immune cells and may couple metabolic adaptation to immune …
Neuroinflammation is a common pathological feature of diverse brain diseases, but inflammatory activity is rarely distributed uniformly across diseased tissue. Instead, microglia, astrocytes, infiltrating immune cells and inflammatory mediators are oft…
ObjectiveSepsis is a life-threatening condition with high mortality and complex pathology. Early diagnosis is critical but remains challenging due to a lack of effective biomarkers. This study aims to identify specific diagnostic markers to distinguish…
Age-related macular degeneration (AMD) is the leading cause of blindness in aging adults, yet no FDA-approved therapies exist for early and intermediate disease. Multiple interconnected pathways, including mitochondrial dysfunction, oxidative stress, a…
ObjectiveSepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection, accounting for an estimated 11 million deaths annually worldwide. Among its most prevalent and severe complications is acute respiratory d…
BackgroundExercise can modulate immune function and inflammatory signaling in cancer populations; however, its effects on the immune system in men with localized prostate cancer undergoing active surveillance are unknown. This study examined the effect…
Aminoacyl-tRNA synthetases (aaRSs) generate the aminoacyl-tRNA pool required for protein synthesis, yet selected family members also participate in nutrient sensing, stress adaptation, metabolite-dependent protein modification and extracellular immune …
Antibiotics, especially broad-spectrum types, disrupt the gut microbiota by indiscriminately killing both pathogenic and beneficial bacteria, leading to dysbiosis. This dysbiosis directly contributes to an imbalance in metabolites, such as short-chain …
MethodepiTOol is a web-based application for transplantation immunogenetics and immunology, providing easy and reliable translation of high-resolution HLA typing into either predicted or confirmed epitopes. Unacceptable or acceptable HLA incompatibilit…
