BackgroundThe formalin-inactivated Coxiella burnetii virulent phase I vaccine (PIV) has been shown to be more protective than the avirulent phase II vaccine (PIIV) against virulent C. burnetii challenge in animal models. However, the cellular and molec…
SAPHO syndrome is a rare autoinflammatory disorder with osteoarticular and cutaneous involvement. Paradoxical skin lesions have been reported during treatment with tumor necrosis factor-α (TNF-α) inhibitors. We describe a 42-year-old man with a 6-year …
Natural killer (NK) cells play a key role in immune defense against tumors and viral infections through a balance of activating and inhibitory receptors. CD99 is a transmembrane glycoprotein involved in many biological processes; however, its role in N…
BackgroundWhile papillary thyroid carcinoma (PTC) generally exhibits a favorable prognosis, a subset of patients experiences poorer outcomes, with lymph node metastasis (LNM) significantly increasing the risk of recurrence and correlating with a worse …
ObjectivesThis study aimed to investigate plasma metabolomic and lipidomic profiles in rheumatoid arthritis (RA) to identify potential biomarkers for distinguishing treatment responses.MethodsPlasma samples were collected from 106 RA patients and 10 he…
Relapsing polychondritis (RP) is a rare and complex autoimmune disease primarily affecting cartilage tissue. In particular, RP leads to inflammatory damage of airway cartilage, resulting in severe complications such as airway narrowing and tracheomalac…
The tumor microenvironment (TME) is a well-documented, complex, and dynamic ecosystem traditionally considered among three major axes: 1) malignant cells, 2) stromal cells, and 3) infiltrating immune cells; all whose interactions have been assumed to s…
BackgroundMicrobiome studies in post-stroke cognitive impairment (PSCI) have focused on the gut, while upstream oral dysbiosis and oral–gut axis signatures remain undercharacterized. We profiled paired oral and gut microbiota in PSCI to assess coordina…
Immune-mediated inflammatory arthritides (IMIA), including rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, and juvenile idiopathic arthritis, are chronic immune-driven disorders in which long-term malignancy safety has become a key …
