Immune checkpoint inhibitors (ICI) have revolutionized the treatment of TNBC, leading to durable responses and improved survival. With the adoption of immunotherapy into high-risk early-stage and selected metastatic triple-negative breast cancer (TNBC)…
BackgroundKey features of gastric cancer (GC) include its aggressive nature, high metastatic capability, and a tendency for relapse. While 5-fluorouracil (5-FU) remains a cornerstone of GC treatment, its efficacy is substantially undermined by the emer…
Human leukocyte antigen (HLA) molecules mediate peptide presentation and shape immune recognition, with clinical relevance well beyond donor-recipient matching. This review describes how HLA variation and anti-HLA immunity affect transfusion medicine, …
BackgroundLung adenocarcinoma (LUAD), the most prevalent histological subtype of non-small cell lung cancer (NSCLC), is characterized by substantial clinical heterogeneity and a frequent propensity to acquire resistance to targeted therapies. Accumulat…
IntroductionSerological monitoring is needed for the real-world evaluation of immune responses after human papillomavirus (HPV) vaccination, but the pseudovirion-based neutralization assay (PBNA) is difficult to apply at scale.MethodsThis study compare…
Skeletal muscle dysfunction (SMD) is a clinically important extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD) and is associated with impaired exercise capacity, reduced physical function, increased exacerbation risk, and poor…
BackgroundObesity is a major risk factor for severe COVID-19, yet the immunological mechanisms by which it modifies disease progression remain incompletely characterized. We aimed to dissect the independent and interactive contributions of obesity and …
Photodynamic therapy (PDT) is an established local treatment for actinic keratoses, Bowen disease, and selected low-risk basal cell carcinomas, but its potential to reshape antitumor immunity may extend its value beyond direct phototoxicity. We conduct…
IntroductionSystemic autoimmune rheumatic diseases (SARDs) are associated with a higher risk of cardiovascular diseases. During pregnancy, maternal immune disbalance might impact the vasculature of the newborn. We, therefore, aimed to investigate a pos…
