IntroductionThe molecular heterogeneity of colorectal cancer (CRC) profoundly shapes clinical outcomes and treatment response, underscoring the need to elucidate the underlying mechanisms to refine diagnosis and therapy. Although LGALS3, which encodes …
BackgroundHelminth infections are among the most prevalent neglected tropical diseases, causing an enormous impact in health and the socioeconomic status of developing countries. The study host-parasite interactions constitute a promising approach for …
IntroductionRenal cell carcinomas (RCC) are resistant to chemotherapy and radiotherapy, and effective treatment options remain limited. Immunotherapy has emerged as a promising approach, and circular RNAs (circRNAs) are increasingly recognized as key r…
BackgroundAsthma remains a global health burden, affecting over 300 million individuals worldwide, with its pathogenesis involving complex interactions between genetic predisposition and environmental allergens. Pollen is a well-established trigger of …
IntroductionT regulatory cells (Tregs) are pivotal for immune tolerance. Among the suppression mechanisms attributed to Tregs, the release of small extracellular vesicles (sEV) has been proposed with CD73, Nrp1 and the transfer of key miRNAs playing a …
Perioperative neurocognitive disorders (PNDs) are common postoperative complications, particularly in elderly patients. While surgical trauma is known to trigger systemic inflammation, the mechanisms linking peripheral immune activation to perioperativ…
Tissue-resident memory T cells (Trm) are a subset of memory T cells that establish residency in peripheral tissues and do not re-enter circulation under homeostasis, playing a central role in local immune responses. Recent studies have revealed that Tr…
Resveratrol (RES), a naturally occurring polyphenolic compound found in grapes, berries, and peanuts, has attracted considerable interest because of its antioxidant, anti−inflammatory, and neuroprotective properties. This narrative review examines the …
Oxidative stress and inflammation are interconnected drivers of cellular damage in pathologies ranging from neurodegenerative disorders to sensorineural hearing loss. We aimed to develop a chitosan-Prussian blue nanozyme (CS-PB) to target these process…
This review systematically summarizes the central roles and molecular mechanisms of the cytoskeletal system—including actin filaments, microtubules (MT), intermediate filaments, and the Septin family—in the regulation of autophagy. The cytoskeleton not…
