Tertiary lymphoid structures (TLS) have evolved from descriptive histological findings into candidate biomarkers and targetable immune niches in solid tumors. In intrahepatic cholangiocarcinoma (ICC), however, similar lymphoid architectures may have di…
Postbiotics have attracted attention owing to their safety and immunomodulatory effects. The heat-inactivated lactic acid bacterium Enterococcus faecalis EF-2001 (EF-2001) is one such postbiotic. Extensive studies on EF-2001 have demonstrated its safet…
BackgroundDespite the prominent immune dysregulation in psoriasis, the organization of peripheral blood γδ T cell states remains incompletely defined.MethodsHere, we performed single-cell transcriptomic profiling of enriched peripheral blood-derived γδ…
Circulating tumor DNA (ctDNA) is emerging as a minimally invasive biomarker for risk stratification and treatment-response assessment in lung cancer immunotherapy, but its routine use for treatment selection has not been established. This review critic…
IntroductionDiabetic kidney disease (DKD) is fundamentally a podocytopathy in which sterile inflammation plays a central pathogenic role, yet the upstream triggers that initiate inflammatory cascades in podocytes remain elusive. R-loops are critical re…
BackgroundMitochondrial dysfunction has been implicated in the pathophysiology of sepsis. However, human genetic evidence linking mitochondria-related genes to sepsis susceptibility remains limited. This study aimed to identify mitochondria-related gen…
Chronic obstructive pulmonary disease (COPD), severe asthma, and asthma–COPD overlap (ACO) represent a major global burden of chronic airway inflammation, often remaining inadequately controlled by current corticosteroid and biologic therapies. Neutrop…
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which genetic susceptibility interacts with epithelial, immune, and mesenchymal remodeling. Although the chromosome 11p15.5 locus contains established IPF susce…
BackgroundBispecific antibodies (bsAbs) have rapidly emerged as one of the most promising therapeutic strategies in oncology because of their ability to simultaneously engage multiple molecular targets and enhance antitumor immunity. Although the numbe…
Welding fumes are widely recognized occupational aerosols, yet their effects on respiratory immune pathways remain incompletely integrated into exposure-oriented assessment. Generated by welding materials, process parameters, surface conditions, and ve…
