BackgroundDiabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and is characterized by progressive glomerulosclerosis, tubulointerstitial fibrosis, and a chronic inflammatory microenvironment. Although macrophage infiltra…
Myasthenia gravis (MG) is a chronic autoimmune disorder of the neuromuscular junction characterized by fluctuating skeletal muscle weakness. Although the pathogenic roles of autoantibodies targeting the acetylcholine receptor (AChR), muscle-specific ki…
BackgroundThe role of neutrophil extracellular traps (NETs) in cervical cancer (CC) progression, particularly their association with human papillomavirus (HPV) infection, remains unclear.MethodsWe analyzed public single-cell RNA sequencing data to expl…
The comorbidity of chronic hepatitis B and metabolic dysfunction-associated fatty liver disease involves a bidirectional “virus–metabolism” interaction mechanism, presenting a clinical paradox characterized by improved virological markers alongside an …
BackgroundVascularized composite allotransplantation (VCA) enables functional and aesthetic restoration after devastating tissue loss. Yet, data-driven profiling of VCA recipients remains scarce. Identifying demographic and procedural patterns may impr…
IntroductionHypereosinophilic syndrome (HES) is defined by persistent hypereosinophilia Q5 associated with eosinophil-mediated organ damage. However, the relationship between HES etiology and organ-involvement patterns remains incompletely defined, par…
Neutrophils are essential for maintaining intestinal mucosal balance during ulcerative colitis (UC). The long noncoding RNA known as nuclear paraspeckle assembly transcript 1 (NEAT1) is associated with various inflammatory disorders. Nonetheless, the r…
BackgroundPredicting occult lymph node metastasis in early-stage tongue squamous cell carcinoma remains a clinical challenge because traditional markers, such as depth of invasion, exhibit limited accuracy. This study aimed to identify spatial immunolo…
Allergic rhinitis (AR) is a chronic inflammatory disease with rising global prevalence and a substantial public health burden. Current treatments have limited efficacy and tolerability, highlighting the need for new strategies. Probiotics represent a p…
IntroductionSimvastatin (SIM), a member of the statin family, is commonly used to lower blood cholesterol levels, particularly low-density lipoprotein. Statins inhibit the action of hydroxy-methyl-glutaryl-coenzyme A reductase, an important enzyme in t…
