Generalized eruptive histiocytosis (GEH) is a rare non-Langerhans cell histiocytosis characterized by multiple symmetrical papular eruptions. We describe an atypical presentation of GEH in a 60-year-old man with scattered S-100 immunopositivity and ser…
BackgroundCervical cancer is one of the leading causes of cancer-related mortality among women worldwide. While immune checkpoint inhibitors combined with bevacizumab and chemotherapy are emerging as the standard first-line therapy for recurrent or met…
BackgroundCadonilimab, a bispecific PD-1/CTLA-4 antibody, has activity in recurrent/metastatic cervical cancer (R/M CC), but high costs limit accessibility, especially in low- and middle-income countries. Hence, we aimed to assess whether lower dose of…
BackgroundPost-menopausal osteoporosis (PMO) is characterized by senescence, estrogen deficiency, immune dysregulation and progressive bone loss, yet the molecular alterations involved in PMO remain incompletely understood.MethodsSingle-cell and transc…
BackgroundPathological NETosis contributes to immune dysregulation and organ damage in systemic lupus erythematosus (SLE), positioning it as a potential therapeutic target. Previous studies have shown suppressed NETosis in term low birth weight (tLBW) …
ObjectiveMacrophage activation syndrome (MAS) is a severe, life-threatening complication in pediatric rheumatic diseases. Current treatments are predominantly based on glucocorticoids; however, their long-term use is associated with significant adverse…
BackgroundPrimary Sjögren’s syndrome (pSS) and type 1 diabetes mellitus (T1DM) share immune-inflammatory features, yet conserved pathogenic signatures linking these autoimmune disorders remain incompletely understood. The present research sought to unc…
Hemolytic anemias comprise inherited and acquired disorders characterized by premature red blood cell destruction. Increasing evidence indicates that many forms of hemolysis are accompanied by sustained inflammatory and immune activation. Red blood cel…
IntroductionMicroglial activation drives neuroinflammation through a metabolic switch from oxidative phosphorylation to aerobic glycolysis; however, the molecular mechanisms governing this transition remain poorly defined. Glyceraldehyde-3-phosphate de…
