Diabetic foot ulcers (DFUs) represent a devastating complication of diabetes mellitus, affecting approximately 25% of diabetic patients and contributing significantly to morbidity, mortality, and healthcare costs worldwide. Chronic non-healing wounds i…
IntroductionEscherichia coli remains amongst the most globally important pathogens implicated in severe clinical manifestations. The progressive rise in multidrug-resistant strains highlights the urgent need for new vaccines. Therefore, this study was …
Osteoarthritis (OA) is a disorder of the whole-joint microenvironment involving mechanical loading, aging, metabolic stress, and dysregulated immune homeostasis. Within the OA joint microenvironment, senescent chondrocytes, synovial fibroblasts, and di…
BackgroundCerebral amyloid angiopathy (CAA) is a common age-associated cerebrovascular disease marked by amyloid-β (Aβ) accumulation in cerebral vessel walls, and it is tightly linked to Alzheimer’s disease (AD) and cognitive impairment. However, the s…
Lymphocyte activation gene 3 (LAG3) has become an important immune checkpoint receptor, which plays a crucial role in regulating the immune response. The immunoregulatory function of LAG3 is achieved through complex receptor-ligand interactions, struct…
BackgroundHepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) carries a poor prognosis. Although SBRT combined with cadonilimab and lenvatinib has shown encouraging antitumor activity in a prior prospective phase II trial, marked inte…
Rhinovirus is the main pathogen causing common colds, acute exacerbations of asthma, chronic obstructive pulmonary disease and other respiratory diseases. Due to its numerous serotypes and the lack of common conserved viral targets, the development of …
BackgroundTumor-associated macrophages (TAMs) play a critical role in lung cancer progression, immune evasion, and treatment resistance within the unique, tissue-specific pulmonary immune microenvironment. However, a comprehensive bibliometric synthesi…
BackgroundAberrant tissue repair and relentless fibroblast activation are hallmark features of idiopathic pulmonary fibrosis (IPF). Although IPF and Alzheimer’s disease (AD) share underlying aging-related pathologies, including immune and metabolic dys…
