IntroductionPembrolizumab, an immune checkpoint inhibitor (ICI) targeting programmed cell death protein 1 (PD-1), has demonstrated significant clinical value in the treatment of human epidermal growth factor receptor 2 (HER2)-negative advanced gastric …
BackgroundPreeclampsia is a pregnancy disorder endangering maternal and fetal health, often accompanied by complications such as hypertension and proteinuria. Natural killer cells are indispensable in the occurrence and development of preeclampsia. Up …
ObjectivesThe aim of this study was to characterize the genetic basis of Behçet’s disease (BD) and mimics in a pediatric cohort.MethodsWe retrospectively studied 34 patients of pediatric BD and mimics who underwent whole-exome sequencing (WES) in our c…
Human leukocyte antigen (HLA) polymorphism shapes antigen presentation and susceptibility to immune-mediated disease. In neuroimmune disorders, a central question is how HLA-dependent antigen visibility becomes disease-specific immunity and tissue inju…
IntroductionTissue-derived chemokines can direct immune cell migration by engaging specific receptors, thereby controlling the localization and trafficking of immune cells within tissues. However, how chemokines modulate cytokines-driven transcriptiona…
The human leukocyte antigen (HLA) system plays a critical role in determining the outcomes of hepatitis B virus (HBV) infection, yet the genetic mechanisms underlying occult HBV infection (OBI), a form marked by detectable HBV DNA in the absence of hep…
IntroductionTargeted-release budesonide (Nefecon) has demonstrated efficacy in IgA nephropathy (IgAN) trials, yet real-world data across disease severity spectrum remains limited.MethodsThis multicenter, retrospective cohort study included 148 biopsy-p…
BackgroundThe prevalence of food allergy has been rising over the past decade, but effective treatments remain limited. The purpose of this study was to investigate the effect of ginkgolide B (GB), a natural bioactive compound with well-documented anti…
ObjectiveGlioma is the most common and aggressive primary intracranial tumor. Its clinical management is substantially hindered by the blood–brain barrier (BBB) and the immunosuppressive tumor microenvironment (TME). This study aimed to construct PD-1-…
