Real world inhalation exposures occur as temporally staggered mixtures of environmental pollutants and indoor allergens, yet the mechanistic consequences of sequential exposure remain poorly defined. Here, we investigated whether diesel exhaust particl…
IntroductionThe treatment of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome has largely focused on immunosuppression with little impact on the atopic manifestations of the disease. Dupilumab therapy has been used succes…
IntroductionSMARCA4‑deficient non‑small‑cell lung cancer (SMARCA4‑dNSCLC) is a rare, aggressive NSCLC subtype driven by SWI/SNF complex dysfunction with no standardized therapeutic strategies. Although chemoimmunotherapy represents standard first‑line …
Hashimoto’s thyroiditis (HT) is the most prevalent autoimmune thyroid disease, characterized by lymphocytic infiltration and destruction of thyroid follicular architecture. Prior research has predominantly focused on aberrant adaptive immune activation…
BackgroundNeuroinflammation is increasingly recognized as a key contributor to epileptogenesis and epilepsy progression. Interleukin-18 (IL-18), a pro-inflammatory cytokine of the interleukin-1 family, has been implicated in seizure susceptibility, whe…
IntroductionNovel immunotherapeutic strategies engaging human Natural Killer (huNK) cells have emerged as a promising treatment paradigm; however, their accurate preclinical evaluation requires reliable mouse models capable of supporting functional huN…
Rheumatic and autoimmune diseases have long relied on glucocorticoids and immunosuppressants for disease control, yet a true cure remains elusive; patients oscillate between remission and relapse and progressively accumulate irreversible organ damage. …
ObjectivesThe host’s immune function, inflammatory response, and nutritional status are closely related to the occurrence and development of neurosyphilis (NS). Asymptomatic neurosyphilis (ANS), as a completely curable type of NS, has received limited …
BackgroundThe global spread of monkeypox represents a significant public health challenge. Vaccination is the cornerstone of pandemic control, and understanding the psychological factors underlying vaccination decisions is crucial. This study aimed to …
