IntroductionTuberculosis (TB) remains the deadliest infectious disease in humans; however, a robust immune response can either protect against or control the infection. Household contacts of TB patients can remain uninfected for decades, while a quarte…
The ability of CD8 T cells to mediate protective immunity while limiting immunopathology depends on critical transcription factors such as Smad4 and Eomes that regulate differentiation of activated CTLs. Disruption of transcriptional programs mediated …
IntroductionPre-exposure prophylaxis (PrEP) with tenofovir/emtricitabine (TDF/FTC) is highly effective for HIV prevention. While antiretroviral therapy (ART) is linked to chronic inflammation in people living with HIV, its direct effects on immune phen…
ObjectivesWe assessed the frequency of adverse drureactions (ADRs) to immunoglobulin products, associated switching patterns, and tolerability after switching in clinical practice.MethodsThis observational, retrospective study was conducted at a single…
Neonatal neutrophils are often described as immature effector cells with limited marrow reserves and reduced antimicrobial capacity. This account is clinically useful but incomplete: individual functions mature at different rates, neutrophil population…
BackgroundRecurrent idiopathic recurrent pericarditis (RP) is increasingly recognized as an organ-specific autoinflammatory syndrome driven by the interleukin-1 (IL-1) axis. Behçet’s Disease (BD), a systemic vasculitis, exhibits significant pathogeneti…
BackgroundChronic eosinophilic pneumonia (CEP) is a rare, idiopathic inflammatory lung disease characterized by subacute symptoms such as cough, dyspnea, and fever; abnormal chest imaging findings; peripheral eosinophilia; and eosinophilic infiltration…
Lymphovascular invasion (LVI) describes intravasated tumor cells within intratumoral lymphatic or blood vessels. LVI is reported routinely on pathologic examination because it is prognostic for reduced disease-free and overall survival across many soli…
BackgroundHepatitis C virus (HCV)-associated B-cell non-Hodgkin lymphomas represent a compelling model of virus-driven oncogenesis in which immune evasion and viral persistence sustain chronic antigenic stimulation, B-cell clonal expansion and progress…
