Laryngeal squamous cell carcinoma (LSCC) shows a persistently low objective response rate to immune checkpoint inhibitors (ICIs) targeting the programmed death-1 (PD-1) pathway. Its immunosuppressive tumor microenvironment (TME), enriched in tumor-asso…
Triple-negative breast cancer (TNBC) is a subtype of breast cancer associated with a poor prognosis; conventional treatments provide limited durable benefit, and resistance commonly develops. The introduction of immune checkpoint inhibitors (ICIs) has …
Risk assessment before allogeneic hematopoietic stem cell transplantation (alloHSCT) is essential to estimate treatment-related morbidity and mortality; the hematopoietic cell transplantation-comorbidity index (HCT-CI) is widely used. The modified Glas…
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide. The tumor microenvironment (TME) is a highly immunosuppressive niche shaped by aberrant angiogenesis, chronic inflammation, and extracellular matrix remodelin…
BackgroundPancreatic adenocarcinoma (PDAC) is an abysmal disease with poor clinical outcomes, largely due to limited life-extending treatments. Notably, PDAC displays a T cell-suppressive tumor microenvironment, and the underlying molecular mechanisms …
Impaired renal urate excretion is a major mechanism underlying hyperuricemia and gout, with urate transporter 1 (URAT1), encoded by SLC22A12, playing a central role in proximal tubular urate reabsorption. This review summarizes the biological relevance…
Invariant natural killer T (iNKT) cells are promising candidates for allogeneic cellular immunotherapy, but the metabolic pathways that support their effector function in nutrient-limited tumor microenvironments remain poorly defined. Human iNKT cells …
Copper is considered a necessary trace element that plays crucial roles in energy production in mitochondria, redox regulation, and metabolism. Copper homeostasis disturbance may promote tumor initiation and progression and therapy resistance. Cupropto…
IntroductionCommon variable immunodeficiency (CVID) is the most frequent symptomatic inborn error of immunity (IEI) in adults and is characterized by recurrent infections, immune dysregulation, and an increased risk of malignancy. Cancer represents a m…
BackgroundImmunotherapy spans tumor and non-tumor disciplines, yet the surge in randomized controlled trials (RCTs) has not yielded proportional improvements in evidence quality, leading to substantial research waste. In this study, the immunotherapy R…
