Frontiers in Immunology
Establishing an untargeted lipidomics workflow for cellular analysis: insights into endothelial cell function in anaphylaxis
BackgroundCell metabolomics, including lipidomics, presents several challenges regarding analyzing limited cell populations and distinguishing cellular metabolites from background signals originated from a stimuli or after a treatment. To address this,…
PD-1 blockade does not enhance alloimmunization after allogeneic dendritic cell vaccination in cancer patients
BackgroundBlocking programmed cell death protein 1 (PD-1) has become a standard cancer immunotherapy, increasingly used in kidney, liver, or heart transplant recipients who develop skin cancer or hepatocellular carcinoma, despite the increased risk of …
Cytokine imbalance and HBV-specific T-cell exhaustion predict disease progression in HIV-HBV coinfection
BackgroundHIV-HBV coinfection accelerates liver disease, yet the immunological mechanisms underlying adverse outcomes remain incompletely characterized in African populations. We investigated relationships between HBV reactivation, cytokine dysregulati…
Cloning, expression and characterisation of antigen-specific recombinant bat immunoglobulin from the black flying fox (Pteropus alecto)
Bats are natural reservoir of viruses that cause severe disease in livestock and humans. Recent high-profile spillover events have directed significant attention towards the relationship between zoonotic viruses and antiviral immunity inherent to bats….
Immune checkpoint inhibitor-induced bullous pemphigoid: a systematic review of clinical characteristics and outcomes based on case reports
ObjectiveImmune checkpoint inhibitor-induced bullous pemphigoid (ICI-BP) is a rare and complex cutaneous immune-related adverse event (cirAE) that often impacts the continuation of ICI therapy. Currently, there are no prospective clinical studies addre…
The involvement of miRNAs in the enhanced immune response of oysters via haemocyte-mediated immune priming
Immune priming enhances innate immunity, leading to a sustained and augmented response upon secondary challenge. The emerging evidence has highlighted the crucial role of endogenous microRNAs in trained immunity of vertebrates. However, the regulatory …
Established and emerging non-cellular therapies in inherited bone marrow failure syndromes
Inherited bone marrow failure syndromes (IBMFs) are a molecularly heterogeneous group of genetically-determined syndromes with a wide spectrum of clinical abnormalities and risk of hematopoietic neoplasia and reduced life expectancy. The prevalence is …
A single-cell immune atlas of primary and secondary lymphoid organs in pigs
Single-cell RNA sequencing (scRNA-seq) has revolutionized understandings of cellular identities and functions due to the ability to study transcriptome-wide gene expression within individual cells. Multi-tissue scRNA-seq atlases have generated holistic…
Prognostic value of baseline circulating tumor DNA levels in metastatic castration-resistant prostate cancer: a systematic review and meta-analysis
BackgroundMetastatic castration-resistant prostate cancer (mCRPC) remains a clinically aggressive and lethal disease. Circulating tumor DNA (ctDNA), as a minimally invasive biomarker, has shown prognostic utility in several solid tumors. However, its c…