Adult T-cell leukemia/lymphoma (ATLL) is an aggressive HTLV-1-associated T-cell neoplasm, and durable control of relapsed/refractory disease remains difficult without allogeneic hematopoietic stem cell transplantation. Mogamulizumab, an afucosylated an…
Athymic mice are widely used in preclinical research to study tumor growth, metastasis, and the efficacy of conventional and targeted therapies. However, these animals are profoundly deficient in thymus-derived conventional T cells while retaining B ce…
Background and objectiveAlveolar echinococcosis (AE) is a fatal zoonotic parasitic disease that causes progressive hepatic injury through chronic inflammation, aberrant proliferative repair, and liver fibrosis. GHSR and TLR4 individually regulate hepat…
IntroductionThis study addresses automatic detection of skin changes especially asymmetry and symmetry of the lesions and their crucial role in the definition of dermatological asymmetry measure.MethodThe present research employs an integrated methodol…
Urothelial carcinoma (UC) remains a persistent clinical challenge in the post-Bacillus Calmette-Guérin (BCG) era, particularly because a substantial proportion of patients with high-risk non-muscle-invasive bladder cancer (NMIBC) experience recurrence …
BackgroundChronic inflammatory rheumatic diseases, such as ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic arthritis, are collectively referred to as spondyloarthropathies (SpA). However, Real-world evidence on the eff…
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease of the esophagus in which symptoms, histologic activity, endoscopic severity, epithelial dysfunction, and fibrostenotic remodeling frequently diverge. Peak eosinophil density remains …
Anti-p200 pemphigoid is a rare autoimmune subepidermal blistering disease with limited evidence guiding its management. We report a 49-year-old woman with refractory anti-p200 pemphigoid who failed treatment with high-dose prednisone and dapsone and de…
Modern disease-modifying therapy has transformed rheumatoid arthritis. Even so, many patients cycle through biological and targeted synthetic drugs of distinct mechanisms without achieving sustained remission. This is the difficult-to-treat phenotype d…
BackgroundPathological response after neoadjuvant chemotherapy is a key treatment milestone in osteosarcoma. We evaluated whether a rule-derived preoperative peripheral inflammatory-lymphocyte recovery phenotype constructed from routinely collected lab…
