Frontiers in Immunology
Toward a chemotherapy and allo-HSCT free future: the evolution of treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia
The treatment landscape for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) has undergone a profound transformation over the past two decades. The integration of BCR-ABL1 tyrosine kinase inhibitors (TKIs) has shifted the paradig…
Next-generation intranasal influenza vaccines: mechanisms, platforms, and translational progress
Seasonal influenza vaccination remains the most effective strategy for reducing influenza burden and preventing severe disease. Despite decades of vaccine development, the seasonal influenza vaccine is administered intramuscularly and provides suboptim…
Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a microbiota-humanized mouse model
Early-life host-microbe interactions critically shape immune development, lifelong homeostasis, and disease susceptibility. The PRIMAL trial (Priming Immunity at the Beginning of Life) demonstrated that multistrain probiotics shifted the gut microbiota…
Integrative multi-omics and radiomics reveal a TMSB10-driven cell state for non-invasive assessment and precision stratification in breast cancer
BackgroundTumor cell heterogeneity is a fundamental driver of breast cancer aggressiveness, underlying recurrence, metastasis, and therapy resistance. Understanding the biological characteristics and functions of specific tumor cell clusters in the tum…
Intranasal VACV VR-1354 infection impairs chemosensory function and induces olfactory bulb neuroinflammation in mice
Vaccinia virus (VACV) and monkeypox virus (MPXV) are closely related members of the family Poxviridae, genus Orthopoxvirus, both capable of causing systemic infections with potential neurological complications. Although live, replication-competent VACV…
The impact of β-glucan yeast extract treatment on melanoma development, tumor-cell deposit infiltration, and immune response
IntroductionMelanoma is one of the most aggressive types of tumors, and strategies for modulating the immune response have been explored as adjuvant therapies. One notable candidate is β-glucan, a polysaccharide derived from Saccharomyces cerevisiae (S…
Integrative analysis of vitamin D, ferritin, and eosinophilic inflammation in predicting acute exacerbations of childhood asthma
BackgroundVitamin D and iron metabolism are increasingly recognized as potential modulators of airway inflammation, yet their interrelationship in pediatric asthma remains unclear. This study investigated the associations of serum vitamin D, ferritin, …
The case for evaluation of double mutant heat-labile toxin as an adjuvant to improve oral cholera vaccine immunogenicity
Cholera has re-emerged as a major global public health threat. Orally administered attenuated or inactivated vaccines offer protection against enteric pathogens such as Vibrio cholerae, and several World Health Organization-prequalified oral cholera va…