BackgroundTertiary lymphoid structures (TLSs) are key immune niches involved in antitumor immunity. However, their functional impact depends on spatial localization, maturation status, and cellular composition within the tumor immune microenvironment (…
Traditionally associated with Th17-mediated pathways, palmoplantar pustulosis (PPP) is a persistent inflammatory dermatosis limited to the palms and soles. However, therapeutic responses to IL-17/IL-23 suppression are often limited, indicating signific…
BackgroundSepsis poses significant challenges in early detection and treatment due to its heterogeneous nature and overlaps with other conditions, such as pneumonia. Identifying reliable biomarkers is crucial for intervention and outcomes.MethodsA tota…
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, yet durable benefit remains limited to selected patients. Established biomarkers, including PD-L1 expression, tumor mutational burden, and microsatellite instability, remain predomi…
IntroductionPorcine tonsils are follicle-rich secondary lymphoid organs positioned at the oropharyngeal interface. In pigs, a major livestock species, they serve as a primary barrier against inhaled and ingested pathogens and play a central role in muc…
BackgroundAlopecia areata (AA) is a T cell–mediated autoimmune disease characterized by systemic immune activation that may extend to ocular tissues. However, whether AA increases the long-term risk of glaucoma remains unclear.MethodsWe conducted a mul…
Sequential or concurrent thoracic radiotherapy and immune checkpoint inhibitors (ICIs) increase the risk of severe overlapping pulmonary toxicity. Progressive pneumonitis after thoracic radiotherapy and ICI exposure remains a clinically challenging con…
BackgroundKiller-cell immunoglobulin-like receptors (KIR) are highly polymorphic receptors expressed by natural killer (NK) cells that regulate immune responses through interactions with HLA class I ligands. Variation in KIR gene content influences imm…
