BackgroundThe ongoing circulation of SARS-CoV-2 Omicron sublineages continues to threaten vulnerable populations such as individuals with diabetes mellitus. Diabetes is well documented to impair host immune function; however, the correlation between cl…
BackgroundAkt1 and Akt2 isoforms reveal distinct immune-regulatory roles in HSV-1 pathogenesis. Akt3 is a developmentally important protein, and mutations in Akt3 gene are associated with a wide spectrum of developmental disorders, including extreme me…
BackgroundPreformed donor-specific anti-HLA antibodies (DSA) are a major risk factor for antibody-mediated rejection and graft failure in kidney, heart, lung, and other vascularized solid organ transplants. Their clinical significance in pancreatic isl…
BackgroundNeoadjuvant immune checkpoint inhibitors combined with chemotherapy improve pathological complete response in early-stage triple-negative breast cancer, but the consistency of benefit, role of PD-L1 expression, and immune-related toxicity rem…
Phosphorylation is a reversible post-translational modification that dynamically regulates immune responses by reshaping the antigen profiles. Phosphoproteomics and immunopeptidomics studies reveal that phosphorylated peptides (phosphopeptides) are nat…
BackgroundVisceral leishmaniasis (VL) often presents with an atypical and fulminant course in immunocompromised hosts, and treatment faces multiple challenges including drug toxicity, immunosuppressive status, and complications.Case presentationHere we…
BackgroundFusobacterium nucleatum (Fn), a gram-negative oral bacterium, has been implicated in promoting colorectal cancer (CRC) progression by modulating the inflammatory microenvironment. Recent studies have shown that gut microbiota imbalance plays …
BackgroundNon-starch polysaccharides (NSPs) support gut health at low levels but may impair nutrient absorption and trigger inflammation when consumed excessively. Pomegranate peel powder (PPP), rich in punicalagin, ellagic acid, gallic acid, and querc…
A defining histological feature of the intervertebral disc (IVD) in healthy adults is its avascular and alymphatic status, which is closely related to its mode of nutrient supply and local immune homeostasis. Following the onset of intervertebral disc …
BackgroundRising antimicrobial resistance rates require new therapeutic approaches such as antimicrobial peptides (AMPs), which are part of the innate immune defense, as alternatives to antibiotics. In this study, we aim to unravel the antibacterial ac…
