Frontiers in Immunology
Unconventional guardians of the brain: MAIT cells as emerging players in glioblastoma immunity
Glioblastomas (GBM) are an aggressive form of brain cancer with no curative treatment options. While T cell therapies have demonstrated substantial success in combatting blood cancers, their application for solid tumours, including GBM, is hampered by …
Efficacy and safety of B7-H3-targeted antibody-drug conjugates in previously treated small cell lung cancer: a systematic review and meta-analysis with a contextual comparison to topotecan
ObjectiveB7-H3-targeted antibody-drug conjugates (B7-H3-targeted ADCs) have shown promising antitumor effects in patients with previously treated small cell lung cancer (SCLC), yet the available evidence on their efficacy and safety has not been system…
Synchronizing immunity with time: unlocking the potential of chrono-immunotherapy in cancer
Circadian rhythms, an endogenous timing system that enables organisms to adapt to Earth’s rotation, profoundly regulate fundamental physiological processes including cellular metabolism, hormone secretion, and immune surveillance. Recent advances have …
ADHD-anchored partitioning of non-small cell lung cancer genetic covariance identifies CLPTM1L and suggestive innate-immune signals
BackgroundIndividuals with attention-deficit/hyperactivity disorder (ADHD) show an elevated incidence of non-small cell lung cancer (NSCLC), usually attributed to smoking. Innate immune activation and chronic inflammation are implicated in both, yet wh…
Artemisinin ameliorates rheumatoid arthritis through modulation of the IL-17/PI3K/AKT signaling pathway: integrated network pharmacology, bioinformatics, and experimental validation
PurposeArtemisinin regulates the immune system and is applied in RA treatment. Nevertheless, the effectiveness and potential mechanisms of artemisinin in the treatment of RA remain unclear, especially in fibroblast-like synoviocytes (FLSs). This study …
Sex-specific effects of resveratrol and metformin on mitochondrial function and inflammatory activation in a TNF-α-driven human iPSC-derived endothelial dysfunction model
Endothelial dysfunction and mitochondrial impairment are key early events in atherogenesis and exhibit sex-specific patterns. Resveratrol and metformin are cardiometabolic modulators with antioxidative and mitochondrial effects, but their sex-dependent…
Microenvironment-defined priority pathways shape ICD-driven abscopal responses
While radiotherapy excels at local tumor control, it seldom orchestrates durable systemic immunity in the context of metastatic disease. The abscopal effect, the regression of non-irradiated distant lesions following focal irradiation, remains a clinic…
3D chemotaxis chip for investigating natural killer cell migration mechanisms
IntroductionNatural killer (NK) cells are a promising tool for cancer immunotherapy, as they can rapidly recognize and kill cancer cells without prior knowledge of tumor-specific antigens while leaving healthy cells unharmed. However, a major challenge…