IntroductionAvian pathogenic Escherichia coli (APEC) poses a serious challenge to global poultry production, where it causes enteritis, septicemia, and high mortality, resulting in substantial economic losses. Although antibiotics have been traditional…
BackgroundIn neurological disorders associated with autoantibodies against intracellular antigens, response to therapy tends to be poor and is associated with irreversible neuronal death. This study aimed to analyze autoimmune encephalitis (AE) associa…
Fibroblasts, once considered merely passive structural components of tissues, are now recognized as dynamic regulators of the immune microenvironment. Recent advances in single-cell and spatial multi-omics have revealed their profound heterogeneity, sp…
Human cytomegalovirus (HCMV), recognized as the largest known DNA virus in the Herpesviridae family, is widely disseminated throughout the human population and poses a substantial threat to public health. HCMV is highly infectious. A majority of HCMV-i…
BackgroundThis study aims to define a novel molecular subtype of LUAD by integrating multiple omics data. Additionally, we develop and validate an Artificial Intelligence Derived Prognostic Index (AIDPI) that predicts the prognosis of LUAD patients, id…
Exosomes, which are molecular cargo-containing, nanosized extracellular vesicles formed through double invagination of the plasma membrane, have emerged as important mediators of intercellular communication within the gastrointestinal tract. In additio…
ObjectiveFerroptosis, an iron-dependent regulated cell death mechanism, has recently gained attention for its crucial role in tumor progression and immune regulation. Gastric cancer (GC), one of the most common and deadly malignancies worldwide, remain…
Sepsis-induced immunosuppression is a phenomenon characterized by the development of several changes in immunophenotype which predispose to secondary infections and increased mortality risk. Immunomodulatory therapies have yet to reproducibly demonstra…
