BackgroundInterstitial pneumonia with autoimmune features (IPAF) is an exclusionary diagnosis that requires the exclusion of alternative etiologies, including malignancy. Invasive mucinous adenocarcinoma (IMA) of the lung can radiologically and clinica…
Immune checkpoint blockade has changed the therapeutic landscape of cervical cancer, but clinical benefit remains heterogeneous and difficult to predict with single biomarkers. Cervical cancer is a particularly suitable setting for immune-cell profilin…
BackgroundAcute graft-versus-host disease (aGVHD) remains a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study investigated the preventive effects of paeoniflorin (PF), a natural monoterpene glycoside, o…
BackgroundThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the COVID-19 pandemic, which resulted in millions of deaths globally and had profound social, economic, and political consequences. Although effective vaccin…
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) exists not only as a membrane-bound immune checkpoint but also as a naturally secreted soluble isoform (sCTLA-4), generated primarily through exon 3 skipping. This review focuses specifically on spli…
BackgroundPseudomonas aeruginosa pneumonia triggers a complex, dynamic host response, yet the cellular coordination of inflammation and repair remains poorly defined.MethodsWe performed time-resolved single-cell RNA sequencing (scRNA-seq) on murine lun…
BackgroundDrug reaction with eosinophilia and systemic symptoms (DRESS) is a severe delayed drug hypersensitivity reaction that may overlap with secondary hemophagocytic lymphohistiocytosis (HLH). Direct antiglobulin test (DAT)-positive hemolysis durin…
Targeted protein degradation (TPD) harnesses endogenous proteolytic machineries—the ubiquitin–proteasome system and lysosomal pathways—to selectively eliminate disease-causing proteins that are refractory to conventional inhibition. In cancer immunothe…
BackgroundThe prognostic relevance of early peripheral immune profiles after successful endovascular thrombectomy (EVT) remains incompletely characterized. We evaluated whether associations between lymphocyte-subset percentages and 90-day functional ou…
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive HTLV-1-associated T-cell neoplasm, and durable control of relapsed/refractory disease remains difficult without allogeneic hematopoietic stem cell transplantation. Mogamulizumab, an afucosylated an…
