Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyper-inflammatory syndrome most commonly triggered by infection, autoimmune disease, or malignancy. Multiple myeloma (MM)-associated HLH is rare. We report a 70-year-old female who present…
Colorectal Cancer (CRC) accounts for the second highest number of cancer-related mortalities rate worldwide, and its incidence and mortality is expected to continue to increase in the coming years. Over 80% of CRC cases are caused by mutation in the Ad…
Gastrointestinal (GI) cancers, encompassing esophageal, gastric, colorectal, hepatocellular, and pancreatic cancers, represent a major global health burden with persistently high morbidity and mortality. Given the limited therapeutic options and poor p…
Transforming growth factor-β (TGF-β) is one of the most complex and context-dependent cytokines in the immune system. Its signaling pathway regulates differentiation, functions, and microenvironment-specific adaptations of immune cells through Smad-dep…
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but can induce immune-related myocarditis (ICI-MC), a rare yet life-threatening toxicity. This review elucidates the cellular and molecular mechanisms underlying ICI-MC, integrating in…
ObjectivesNeutrophil extracellular traps (NETs) are a crucial mechanism of the neutrophil immune response and exhibit complex dual pathological and physiological effects in pulmonary diseases. In recent years, this research domain has increased signifi…
BackgroundColorectal cancer (CRC) exhibits substantial biological and prognostic heterogeneity that is not fully captured by conventional clinicopathological staging, and the interplay between the cellular senescence and circadian dysregulation in CRC …
Salmonella is a major foodborne pathogen that causes approximately 1.35 million infections annually in the US and remains a leading cause of poultry-associated foodborne illness. To improve chickens’ resistance to this pathogen, it is important to unde…
BackgroundWhile immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, neurological immune-related adverse events (n-irAEs) associated with these agents are increasingly recognized. However, kelch-like protein-11(KLHL11)-IgG cerebellit…
BackgroundRituximab (RTX) represents an established therapeutic option for myasthenia gravis refractory to conventional immunotherapy. However, its heterogeneous efficacy across populations creates a challenge in clinical application, necessitating the…
