BackgroundChronic hepatitis B virus (HBV) infection represents a major global public health issue, affecting hundreds of millions worldwide and serving as a primary cause of cirrhosis and hepatocellular carcinoma. In recent years, immunotherapies aimed…
Exposure to Mycobacterium tuberculosis (Mtb) leads to a spectrum of outcomes, from latent infection to active disease, but limited insight into protective immune correlates has hampered vaccine development. Using a proteome-wide Mtb microarray, we mapp…
Antibody-mediated rejection (AMR) after liver transplantation (LT) is increasingly recognized as a cause of graft dysfunction, chronic injury, and graft loss, but remains difficult to diagnose because serologic, histologic, and clinical findings are of…
BackgroundChaperone-mediated autophagy (CMA) plays an important role in tumor progression and remodeling of the tumor immune microenvironment. However, its functional heterogeneity, immune associations, and clinical significance in colon cancer remain …
Epithelial barrier disruption and mucosal innate immune activation reinforce each other in ulcerative colitis (UC), yet the epithelial glycosylation programs linking mucus homeostasis to inflammatory tissue injury remain incompletely defined. Here, we …
BackgroundPediatric asthma (PA) is a prevalent chronic respiratory disease. Emerging evidence suggests that dysregulated macrophage heterogeneity and immune-metabolic crosstalk contribute to disease pathogenesis, yet specific molecular nodes linking in…
Macrophages, as central players in the tumor microenvironment (TME), exhibit remarkable plasticity, shifting between pro-inflammatory M1 and immunosuppressive M2 states. This polarization directly influences the response to radiotherapy in cancers. Whi…
BackgroundSirolimus (rapamycin), an antibiotic discovered in the 1970s, can effectively reduce allograft rejection, and plays an important role in the fields of immunosuppressive therapy and organ transplantation. Therefore, this study aimed to analyze…
IntroductionPersistent immune activation and inflammation remain significant barriers to managing comorbidities in people living with HIV (PLWH) on suppressive antiretroviral therapy (ART). While ART substantially reduces plasma viral loads to an undet…
BackgroundThe Lymphocyte subsets in treatment-naïve patients and their variations among different genetic subtypes and age groups remain poorly characterized.MethodsTo characterize the distribution of lymphocyte subsets in treatment-naïve thalassemia p…
