IntroductionNutritional strategies have emerged as promising tools to modulate immune responses in marine fish, particularly at mucosal surfaces involved in host-pathogen interactions. Dietary immunomodulators such as yeast-derived β-glucans (BG) have …
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder marked by joint swelling, pain, and progressive tissue destruction. Increasing evidence suggests that dysregulated RNA expression critically drives RA progression by perturbing imm…
BackgroundChronic spontaneous urticaria (CSU) exhibits marked immunologic heterogeneity, and a substantial proportion of patients show delayed or absent responses to anti-IgE therapy. While cytokines are implicated in CSU pathophysiology, their integra…
BackgroundSystemic sclerosis (SSc) is a heterogeneous autoimmune disease in which interstitial lung disease (ILD) is a major determinant of mortality. Given that certain chemokines and adhesion molecules may be involved in the inflammation, subsequent …
ObjectiveThis study explores the mechanism of propofol in autologous orthotopic liver transplantation (AOLT)-insulted kidney injury.MethodsA rat model of OALT-induced kidney injury was established, followed by intraperitoneal injection of propofol. Rat…
IntroductionTuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, and Bacillus Calmette–Guérin (BCG) offers inconsistent protection against adult pulmonary TB. We previously showed that homologous mRNA vaccination encoding the…
BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease, ranging from simple steatosis (MASL) to metabolic dysfunction-associated steatohepatitis (MASH). However, reliable noninvasive strat…
We report a case of a 67-year-old man with rheumatoid arthritis (RA) presenting with symmetrical annular plaques confined to the face. Histopathology demonstrated dense dermal eosinophilia without flame figures, consistent with eosinophilic annular ery…
BackgroundDevelopment of de novo donor-specific antibodies (dnDSA) remains a key risk factor for antibody-mediated rejection and graft loss in kidney transplantation. The PIRCHE-T2 model estimates immunogenicity by predicting donor-derived HLA peptides…
Calcium electrochemotherapy (CaECT) is an effective alternative to standard chemotherapeutic treatments, utilizing intracellular delivery of supraphysiological calcium concentrations to induce cell death. High-frequency sub-microsecond bursts can be su…
