BackgroundOral cholera vaccines (OCVs) show variable immunogenicity in endemic settings. Host factors including enteric dysfunction, systemic inflammation, and nutritional status may influence responses, yet their role in shaping OCV immune responses i…
BackgroundInborn errors of immunity (IEI) predispose patients to malignancy, particularly lymphoma, but data on diagnostic sequence and outcomes are limited.MethodsWe retrospectively analyzed IEI-associated malignancies diagnosed at a single center bet…
IntroductionClear cell renal cell carcinoma (ccRCC) remains a significant therapeutic challenge due to its biological heterogeneity, variable clinical behavior, and limited efficacy of single-agent systemic therapies. Combination strategies targeting m…
BackgroundWith the rising incidence of syphilis in recent decades, the number of patients with syphilis serofast has also increased, posing challenges to clinical management of patients and increasing the social burden.ObjectiveIn this study, we aimed …
Interleukin-33 (IL-33) has long been categorized as a prototypical alarmin released upon cellular injury to initiate Th2-skewed immune responses. However, accumulating evidence from diverse kidney disease models and patient cohorts has unveiled a far m…
BackgroundAutoinflammatory diseases (AIDs) are a heterogeneous group of innate immune-driven disorders whose prevalence is rising globally, yet the lack of disease-specific biomarkers continues to hamper accurate disease activity assessment, phenotype …
Recurrent chylothorax induced by thoracic duct injury in patients complicated with mixed hyperlipidemia secondary to systemic lupus erythematosus (SLE) is rarely encountered in clinical practice. A 55-year-old female patient diagnosed with SLE, whose p…
BackgroundVaccination is the most effective strategy for preventing and controlling infectious diseases in aquaculture. Edwardsiella piscicida, a Gram-negative facultative intercellular bacterial pathogen, is the etiological agent of edwardsiellosis in…
Insects are the most diverse group of animals in nature, occupying nearly every ecological niche and playing central roles as pollinators, pests, and disease vectors. Despite this vast diversity, insects rely on a set of conserved yet evolutionarily ad…
Adult human skin healing is predominantly characterized by fibrosis rather than true regeneration, despite the conserved regenerative principles observed in fetal wound healing, liver regeneration, and other biological systems. Historical and contempor…
