Probiotics have gained wide popularity as environmentally sustainable replacement for antibiotics in aquaculture due to their ability to up-regulate the host immune competence and boost disease resistance. However, considerable knowledge is yet to gain…
ObjectiveResveratrol is a dietary polyphenol found in grapes, peanuts, and berries, with reported anti-inflammatory, immunomodulatory, barrier-protective, and microbiota-regulating properties. Functional dyspepsia (FD) is associated with duodenal immun…
Autoimmune diseases (ADs) are a group of inflammatory disorders triggered by aberrant immune responses against autoantigens and the breakdown of immune tolerance. Current therapeutic strategies, such as glucocorticoids and immunosuppressants, exert lar…
BackgroundKrabbe disease is a rare, rapidly progressive leukodystrophy with high early mortality. Hematopoietic stem cell transplantation (HSCT) is the main disease-modifying intervention used in clinical practice and may act through donor-derived myel…
Graves’ disease (GD) is an autoimmune disorder characterized by the production of stimulatory autoantibodies against the thyrotropin receptor, leading to hyperthyroidism and diffuse goiter. The most frequent extrathyroidal manifestation is Graves’ opht…
BackgroundThe clinical manifestations of anti-synthetase syndrome-associated interstitial lung disease (ASyS-ILD) are highly heterogeneous, and the mechanisms underlying its development and progression remain poorly understood. This study aimed to iden…
Secondary lower-extremity lymphedema has long been regarded primarily as a disorder of impaired lymphatic fluid return. However, growing evidence indicates that its core pathology is a lymph stasis-driven immune–stromal remodeling process characterized…
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus marked by immune complex deposition and tissue-specific inflammation. Advances in single-cell transcriptomics and high-dimensional immune profiling have revealed that CD8+ T…
BackgroundIL-17 pathway inhibitors are established treatments for active psoriatic arthritis (PsA), but comparative evidence within this therapeutic class remains limited. We compared the efficacy, safety, treatment rankings, and certainty of evidence …
