BackgroundSepsis outcomes remain difficult to predict because immune trajectories are heterogeneous and dynamically shift from early activation to immunosuppression. Endotoxin tolerance (ET) in circulating monocytes/macrophages is a key mechanism of se…
With the inherent T-cell immunodeficiency of Schimke immune-osseous dysplasia (SIOD), the management of immunosuppressive therapy after transplantation and life-threatening infections remains a challenge. Here, we present a case of a child with SIOD wh…
Sepsis is a life-threatening condition caused by a dysregulated immune response, often leading to organ failure and death. Diagnosis and therapy remain challenging. This study aimed to identify biomarkers for sepsis through multi-omics analysis and exp…
β-Hydroxybutyrylation (Kbhb) is a novel posttranslational modification (PTM) mediated by β-hydroxybutyrate (BHB). BHB, the core product of ketogenic metabolism, serves as its direct precursor and substrate. As a hub connecting energy metabolism and the…
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive and fatal interstitial lung disease with limited therapeutic options. Recent evidence highlights dysregulated iron metabolism in macrophages as a critical yet underrecognized driver of diseas…
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis in which cardiac involvement is a primary cause of mortality. Complete heart block presenting as Adams-Stokes syndrome is a rare but critical complication. Notably, to o…
Macrophages are the predominant immune cell type found in active multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) lesions, where they contribute to demyelination and axonal damage. Depending on the lesion stage, these cells c…
BackgroundAntihistamines have been reported to be linked with new-onset osteoarthritis (NOO). However, the effect of these drugs on NOO is unclear in patients with autoimmune disease. In this study, we aimed to investigate the effects of an antihistami…
Nasal inflammatory disease has a complex pathogenesis, high incidence and long disease course. Complete resolution is often challenging, and these diseases are closely related to upper and lower respiratory tract diseases. For common nasal inflammatory…
The presence of non-neutralizing antibodies of any dengue serotype increases the severity of subsequent infection by other dengue serotypes. During the SARS-CoV-2 pandemic, the number of symptomatic dengue cases increased in India. We found that antibo…
