inmunoadmin

Exploring the Pathogens in Primary Predominantly Antibody Deficiencies of Unknown Genetic Origin

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J Clin Immunol. 2025 Dec 12. doi: 10.1007/s10875-025-01970-3. Online ahead of print. ABSTRACT INTRODUCTION: Primary ‘predominantly antibody deficiencies’ (PADs) are rare disorders characterized by increased susceptibility to infections, autoimmunity, allergies, and malignancies. Their low prevalence and heterogeneity often delay diagnosis, increasing morbidity and mortality. This study identifies infection patterns in PAD patients and analyzes predictors … Read more

GM-CSF Ameliorates Inflammation from Pseudomonas aeruginosa in a Juvenile Mouse Model of Burn Injury​Julia A Penatzer on 11 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 11:qiaf175. doi: 10.1093/jleuko/qiaf175. Online ahead of print. ABSTRACT Pediatric burn injury induces concurrent systemic inflammation and immune dysfunction, which is associated with adverse clinical outcomes (e.g., infections). For that reason, immunomodulating therapies, such as granulocyte macrophage colony-stimulating factor (GM-CSF), have been of great interest to augment the immune response following … Read more

Antinuclear antibody positivity in acute Epstein–Barr virus and cytomegalovirus infections. Shira Dor Itai Harris Ofek Arviv Daniel Boleslavsky Eleanor Zeruya Michal Tepperberg Oikawa Michal Brodavka Uri Manor a Internal Medicine Department “C”, Sheba Medical Center, Tel HaShomer, Israelb Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israelc Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel HaShomer, Israeld National Center for Herpes Viruses, Sheba Medical Center, Tel HaShomer, Israele Rheumatology Unit, Sheba Medical Center, Tel HaShomer, Israelf Management Wing, Sheba Medical Center, Tel HaShomer, Israel

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Volume 58, Issue 1, December 2025.

Tristetraprolin protects against ozone-induced acute lung injury and inflammation in mice

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J Immunol. 2025 Dec 11:vkaf221. doi: 10.1093/jimmun/vkaf221. Online ahead of print. ABSTRACT Tristetraprolin (TTP) is an anti-inflammatory protein that mediates messenger RNA (mRNA) decay of certain transcripts, especially those encoding proinflammatory cytokines. TTP modulates various pathological outcomes in diverse inflammatory diseases; however, its role in ozone (O3)-induced acute lung injury (ALI) has never been tested. … Read more

Revisiting tryptophan metabolism in cancer: complexity, context, and spatial heterogeneity

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Curr Opin Immunol. 2025 Dec 9;98:102706. doi: 10.1016/j.coi.2025.102706. Online ahead of print. ABSTRACT Tryptophan (TRP) metabolism has long been associated with cancer immunity, primarily through the kynurenine pathway mediated by indoleamine-2,3-dioxygenase 1 (IDO1) and tryptophan-2,3-dioxygenase (TDO2). Both enzymes can deplete TRP within cells and in local microenvironments, triggering dysfunction of T cells with anti-tumor functions. … Read more

Divergent effects of a Treg-selective IL-2 mutein on influenza-specific T cell responses

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J Immunol. 2025 Dec 10:vkaf297. doi: 10.1093/jimmun/vkaf297. Online ahead of print. ABSTRACT Enhancing regulatory T cell (Treg) function offers a compelling therapeutic strategy for autoimmune disease. Engineered IL-2 muteins selectively expand functional Tregs with minimal impact on other immune cells, but their potential to compromise antiviral immunity remains largely unexplored. Here, we used a murine … Read more

IL-2 complex therapy prolongs fully MHC-mismatched murine cardiac allograft survival

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J Immunol. 2025 Dec 10:vkaf303. doi: 10.1093/jimmun/vkaf303. Online ahead of print. ABSTRACT Regulatory T cell (Treg)-biased IL-2/anti-IL-2 monoclonal antibody complexes (IL-2c) can preferentially deliver IL-2 to CD25+ Tregs, causing proliferation of Tregs that is potentially advantageous in transplantation. We tested the ability of IL-2c to prolong murine cardiac allograft survival. C57BL/6 (H-2b) mice received fully … Read more

Exaggerated IFN-I Response in Long COVID PBMCs Following Exposure to Viral Mimics

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J Clin Immunol. 2025 Dec 10. doi: 10.1007/s10875-025-01969-w. Online ahead of print. ABSTRACT PURPOSE: Long COVID (LC) is a long-term debilitating disease of which the exact pathophysiology is unknown. A dysregulated immune response resulting in hyperresponsive immune cells is hypothesized as a key mechanism in the development of LC. Several studies suggest that acute infections … Read more

Cover Story: Eur. J. Immunol. 12’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

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