inmunoadmin Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more
How the immune system of people with diabetes responds to vaccination against respiratory viruses is not well understood. Using activation-induced markers to identify, quantify, and functionally characterize Spike-specific CD4+ and CD8+ T cells after SARS-CoV-2 vaccination, we show defects in T cell memory maintenance and an IL-10 and IL-13-dominated T cell response in people with … Read more
Curr Opin Immunol. 2025 Dec 8;98:102704. doi: 10.1016/j.coi.2025.102704. Online ahead of print. ABSTRACT Clinically overt granulomatous involvement of the nervous system, or neurosarcoidosis, occurs in up to 5% of patients with sarcoidosis. Diagnosing neurosarcoidosis is often challenging due to its highly heterogeneous and frequently nonspecific clinical presentations, as well as the difficulty in obtaining tissue … Read more
Cancer Immunol Res. 2025 Dec 9. doi: 10.1158/2326-6066.CIR-25-0242. Online ahead of print. ABSTRACT Tumor cells employ metabolic mechanisms to limit antitumor immunity and promote resistance to immunotherapy. However, how immunotherapy modulates tumor metabolism remains unclear. Here, we demonstrated that anti-PD-1 treatment regulated cholesterol biosynthesis in cancer cells through the effector cytokine interferon IFN-γ. Mechanistically, IFN-γ-induced … Read more
J Immunol. 2025 Dec 8:vkaf325. doi: 10.1093/jimmun/vkaf325. Online ahead of print. ABSTRACT Freshwater crayfish as most aquatic crustaceans live for up to 20-30 years on the bottom of lakes and rivers, constantly exposed to millions of microorganisms. Consequently, they must have an effective immune system to combat and eliminate pathogens. The main immune cells are … Read more
Cancer Immunol Res. 2025 Dec 8. doi: 10.1158/2326-6066.CIR-25-0070. Online ahead of print. ABSTRACT Vaccines that encode tumour-associated antigens are potent boosting agents for adoptively transferred tumour-specific T cells. Employing vaccines to boost adoptively transferred tumour-reactive T cells relies on a priori knowledge of tumour epitopes, isolation of matched epitope-specific T cells, and personalized vaccines, all … Read more
J Leukoc Biol. 2025 Dec 8:qiaf172. doi: 10.1093/jleuko/qiaf172. Online ahead of print. ABSTRACT Ovarian cancer remains the most lethal gynecologic malignancy, due in part to the establishment of a profoundly immunosuppressive tumor microenvironment (TME). While toll-like receptor 5 (TLR5) signaling has previously been implicated in promoting myeloid cell recruitment to the ovarian TME, source(s) of … Read more
Curr Opin Immunol. 2025 Dec 4;98:102703. doi: 10.1016/j.coi.2025.102703. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a systemic autoimmune disorder marked by chronic immune activation, with a central role attributed to the interferon (IFN) system. The so-called ‘IFN signature’ at both tissue and peripheral levels has long been recognized as a hallmark of SjD, … Read more
Trends Immunol. 2025 Dec 6:S1471-4906(25)00301-1. doi: 10.1016/j.it.2025.11.005. Online ahead of print. ABSTRACT The developmental origins of health and diseases concept posits that early-life exposure to environmental adversities increases risks for diverse noncommunicable and infectious diseases. Among these adversities, maternal malnutrition is a critical determinant of offspring health trajectories. Maternal malnutrition from preconception to lactation can … Read more
Trends Immunol. 2025 Dec 5:S1471-4906(25)00300-X. doi: 10.1016/j.it.2025.11.004. Online ahead of print. ABSTRACT The intestinal epithelium functions as an immune-metabolic interface, integrating environmental signals to maintain systemic homeostasis. Intraepithelial lymphocytes (IELs), interspersed within the epithelial layer, form a highly interactive network with intestinal epithelial cells (IECs) to coordinate barrier defense, immune tolerance, and metabolic regulation. IECs … Read more
