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Beyond proteostasis: the HSF1-HSP axis in inflammation​Gerardo E Ortiz on 18 de August de 2026 at 10:00

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J Leukoc Biol. 2026 Aug 18:qiag115. doi: 10.1093/jleuko/qiag115. Online ahead of print. ABSTRACT Inflammation is a multifaceted response involving molecular and cellular components triggered by diverse stimuli, including physical, chemical, and biological factors. The connection between these stimuli and inflammatory cellular responses involves numerous interactions among molecular components, resulting in cell outputs that can either … Read more

Immunotherapy of malignant melanoma using T cell-activating microbeads

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J Immunol. 2026 Aug 4;215(8):vkag191. doi: 10.1093/jimmun/vkag191. ABSTRACT Metastatic disease is the prime cause of death from many malignancies. Due to the multiple different lesions and the increased aggressiveness of the cancer cells, metastatic disease is often difficult to treat. Here, the introduction of immune checkpoint blockers (ICBs) has greatly helped to improve patients’ prognosis … Read more

Expression and Role of the RNA‐Binding Protein, ZFP36L1, in Mouse T Follicular Helper Cell Differentiation and Function. [[{“value”:”Helena A. Carslaw, Sam Woolliscroft, Emily M. Watson, Sarah E. Bell, Michelle A. Linterman, Martin Turner, Louise M. C. Webb”}]]

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T follicular helper (Tfh) cells support germinal center (GC) B cells, generating long-lived antibody-secreting and memory B cells. RNA-binding proteins likely fine-tune Tfh function, but selective deletion of ZFP36L1 from Tfh cells alters neither their differentiation nor GC responses. This suggests further redundancy within the ZFP36 family. ABSTRACT T follicular helper (Tfh) cells are critical … Read more

Ryanodine Receptor 1 Is Dispensable for CD4+ T‐Cell Differentiation and Effector Function in Intestinal Inflammation Models. [[{“value”:”Sogol Dostiar Tabrizi, Mikolaj Nawrocki, Tanja Bedke, Marius Böttcher, Friederike Stumme, Melina Birus, Franziska Möckl, Lola Hernandez, Björn‐Phillip Diercks, Nicola Gagliani, Dmitri Lodygin, Alexander Flügel, Andreas H. Guse, Hans‐Willi Mittrücker, Samuel Huber”}]]

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Ryr1 deletion reduces Ca2+ microdomains and delays global Ca2+ signaling in naïve CD4+ T cells but does not impair their activation, proliferation, or differentiation in vitro. Despite altered Ca2+ signaling, Ryr1 expression in CD4+ T cells was dispensable for their pathogenicity in murine models of intestinal inflammation. ABSTRACT T-cell receptor (TCR) signaling is necessary for … Read more

Rapid and Highly Efficient CRISPR‐Cas9 RNP Genome Editing in Primary ILC2s. [[{“value”:”Arianna Maria Candelotti, Giordana Garzillo, Sara Bartolini, Chiara Di Censo, Giovanna Peruzzi, Helena Stabile, Cinzia Fionda, Giuseppe Sciumè, Giuseppe Pietropaolo”}]]

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CRISPR-mediated gene editing enables efficient genetic manipulation of ILC2s through ex vivo or in vivo activation and Cas9 RNP delivery. This platform provides a robust approach to dissect gene function in ILC2s, with minimal manipulation.

From Advocacy to Action: The yEFIS Perspective on Women in Immunology and Persistent Barriers. [[{“value”:”Marie‐Louise Diefenbach‐Wilke, Marija Rakić, Ewa Oleszycka, Ines Poljak, Melissa van Gool”}]]

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The yEFIS Women in Science campaigns highlighted the achievements of women in immunology while raising awareness of persistent structural barriers, fostering dialogue, networking and greater recognition of gender equity in science.

Analysis of Human Thymopoiesis Reveals Rapid Postnatal Remodeling of Thymocytes Within the First 3 Months of Life. [[{“value”:”Camille Kergaravat, Jean‐Marc Doisne, Clarisse Godard, Agata Cieslak, Mourad Amrane, David Vermijlen, Vahid Asnafi, Kamel Benlagha, James P. Di Santo, Emmanuel Clave, Antoine Toubert”}]]

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Human thymopoiesis undergoes a dynamic postnatal transition, revealing maximal intrathymic sjTREC production at birth, shifts in thymocyte phenotype and composition, and a transient wave of effector Vδ2+ γδ T cells during early infancy. ABSTRACT The thymus generates a diverse and self-tolerant T-cell repertoire. Its development and output undergo profound changes from fetal to early postnatal … Read more

Isotype-specific antibody secreting plasma cells harbor epigenetic and transcription factor architectures defining distinct cell lineages

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J Immunol. 2026 Aug 4;215(8):vkag231. doi: 10.1093/jimmun/vkag231. ABSTRACT Antibody-secreting cells (ASCs) are critical effectors of humoral immunity, wherein their distinct isotypes play specialized roles in pathogen defense. Despite studies defining the transcriptional programs of selected ASC isotypes, specific mechanisms underlying isotype-specific gene regulation are largely unaddressed. Here, we performed an integrated multiomics analysis (RNA sequencing, … Read more

The multifaceted roles of cellular senescence in liver pathophysiology: from tissue repair to tumor progression. Efi Tsouri

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Semin Immunol. 2026 Aug 17;83:102053. doi: 10.1016/j.smim.2026.102053. Online ahead of print. ABSTRACT Cellular senescence is a stress-response program that coordinates cell-autonomous growth arrest and non-cell autonomous remodeling of the tissue environment. Initially defined through its role in aging and tumor suppression, senescence is now recognized as a highly complex program shaped by cell-intrinsic and environmental … Read more

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