inmunoadmin

Extracellular vesicles from Candidozyma (Candida) auris inhibit proliferation of CD4 T cells by disrupting the IL-2 axis

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J Immunol. 2025 Dec 6:vkaf302. doi: 10.1093/jimmun/vkaf302. Online ahead of print. ABSTRACT Candidozyma auris (formerly Candida auris) is an emerging multidrug-resistant pathogenic fungus that has rapidly spread across the world. Due to the high frequency of multidrug-resistant strains and mortality rate, C. auris is considered a critical health threat by the Centers for Disease Control … Read more

Immune Checkpoint Expression in Mucosal-Associated Invariant T (MAIT) Cells is Stimulus-Dependent​Christy Clutter on 6 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 6:qiaf177. doi: 10.1093/jleuko/qiaf177. Online ahead of print. ABSTRACT Mucosal-associated invariant T (MAIT) cells are unique unconventional T cells with diverse roles in immunity, yet how their context informs their function is not well known. This contextual regulation is particularly relevant in cancer, where MAIT cells have an enigmatic role. We … Read more

The lingering shadow of epidemics: post-acute sequelae across history. Christine M Miller

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Trends Immunol. 2025 Dec 4:S1471-4906(25)00267-4. doi: 10.1016/j.it.2025.10.010. Online ahead of print. ABSTRACT The SARS-CoV-2 pandemic has drawn global attention to post-acute infection syndromes (PAIS), with millions affected by post-acute sequelae of COVID-19 (PASC, or Long COVID). While Long COVID is newly defined, PAIS have been described for over a century following epidemic infections. Multiple pathogens … Read more

Innate recognition and phagocytosis of zymosan by human neutrophils require cell priming in a p38-dependent manner

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J Immunol. 2025 Dec 5:vkaf324. doi: 10.1093/jimmun/vkaf324. Online ahead of print. ABSTRACT Neutrophils are the first line of defense against fungal infection and other microbial pathogens. Through alternative pathway of complement activation in innate immunity, complement fragments (opsonin) generated promote phagocytosis of the yeast forms of fungal pathogens such as Candida albicans. However, when complement … Read more

T cell priming by high avidity neoantigens in lymph nodes augments adoptive immunotherapy

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Cancer Immunol Res. 2025 Dec 5. doi: 10.1158/2326-6066.CIR-25-0514. Online ahead of print. ABSTRACT Adoptive transfer of T lymphocytes specific for tumor-associated neoantigens can elicit immunity against solid tumors in patients. However, how these antigens impact T cell function, effector differentiation, and persistence remains unclear. We examined how an identical CD8+ T cell product was shaped … Read more

Eosinophils（EOS)- The Greek Dawn Goddess of the same name​Jing Wang on 5 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 5:qiaf171. doi: 10.1093/jleuko/qiaf171. Online ahead of print. ABSTRACT Eosinophils (EOS), named after the Greek dawn goddess Eos, are multifunctional granulocytes with roles surpassing their well-established involvement in allergic diseases and parasitic infections. Herein, we highlighted the recent advancements in understanding the cellular structure, lineage development, surface receptors, and diverse phenotypes … Read more

Single cell analysis identifies inflammatory and tissue remodeling tumor associated macrophages distinct from M1/M2 paradigm​Eric López-Huerta on 5 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 5:qiaf176. doi: 10.1093/jleuko/qiaf176. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAM) exert both pro- and anti-tumoral functions that influence cancer progression and patient prognosis. However, single-cell RNA sequencing (scRNA-seq) studies have revealed that TAM heterogeneity remains incompletely characterized. By performing an unbiased, integrated in silico analyses of publicly available scRNA-seq … Read more

Restriction of IgA secretion in gut plasma cells is driven by a tissue-specific glycolytic program

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J Immunol. 2025 Dec 3:vkaf310. doi: 10.1093/jimmun/vkaf310. Online ahead of print. ABSTRACT IgA-secreting plasma cells (PCs) provide durable humoral immunity by supplying critical antibodies to mucosal and systemic sites. These cells are found in large numbers in the gut lamina propria and the bone marrow (BM). In this study, we found that IgA+ PCs in … Read more

Is psoriatic arthritis a dissemination of cutaneous psoriatic TRM cells? Role of tissue-resident memory T cells (TRM) in psoriatic disease

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Curr Opin Immunol. 2025 Dec 2;98:102702. doi: 10.1016/j.coi.2025.102702. Online ahead of print. ABSTRACT Tissue resident memory T cells (TRM) cells are a recently defined subtype of nonrecirculating memory T cells with longevity and protective functions in peripheral tissues. The discovery of T cells resident in diverse tissues has altered our understanding of adaptive immunity with … Read more

The role of non-cancer cell infections in oncolytic virus therapy. Jahanara Rajwani

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Semin Immunol. 2025 Dec 2;81:101998. doi: 10.1016/j.smim.2025.101998. Online ahead of print. ABSTRACT Oncolytic viruses (OV) are designed to seek out and kill cancer cells, while simultaneously inciting potent antitumour immunity. While their exact mechanism of action is incompletely understood, therapeutic activity is proposed to rely on viruses selectively infecting cancer cells – not only to … Read more

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