inmunoadmin Trends Immunol. 2025 Nov 19:S1471-4906(25)00253-4. doi: 10.1016/j.it.2025.10.009. Online ahead of print. ABSTRACT IL-22, produced by various cell types including T helper (Th) 17 cells and group 3 innate lymphoid cells (ILC3s), plays a pivotal role in gut homeostasis by acting on non-hematopoietic cells. It promotes epithelial barrier integrity, tissue repair, and antimicrobial defense. Beyond its … Read more
Trends Immunol. 2025 Nov 20:S1471-4906(25)00269-8. doi: 10.1016/j.it.2025.10.012. Online ahead of print. ABSTRACT Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies revealed that IL-27 also directly modulates CD8+ T cells, displaying both stimulatory and inhibitory potential. Recent work extends this earlier … Read more
J Immunol. 2025 Nov 20:vkaf294. doi: 10.1093/jimmun/vkaf294. Online ahead of print. ABSTRACT The Mycobacterium tuberculosis complex (MTBC), comprising species such as M. tuberculosis, M. africanum, and M. canettii, is the causative agent of tuberculosis (TB), one of the deadliest infectious diseases worldwide. MTBC strains exhibit genetic diversity that influences host-pathogen interactions, immune evasion, and disease … Read more
J Leukoc Biol. 2025 Nov 4;117(11):qiaf152. doi: 10.1093/jleuko/qiaf152. ABSTRACT Sepsis is a life-threatening condition driven by a dysregulated host response to infection, in which the innate immune axis-particularly the crosstalk between neutrophils and macrophages-plays a central role in dictating disease trajectory. This review delineates the functional, metabolic, and spatial characteristics of these two phagocytic cell … Read more
J Leukoc Biol. 2025 Nov 20:qiaf167. doi: 10.1093/jleuko/qiaf167. Online ahead of print. ABSTRACT IRGM proteins are associated with increased susceptibility to Crohn’s disease, mycobacterial infections, sepsis, and other inflammatory diseases, but the cells in which they function in vivo have not been delineated. To address this, mice with conditional deletions of Irgm1 were created and … Read more
Trends Immunol. 2025 Nov 19:S1471-4906(25)00286-8. doi: 10.1016/j.it.2025.11.003. Online ahead of print. ABSTRACT Chi and colleagues revealed that dietary cysteine enhances intestinal stem cell (ISC) regeneration, driving coenzyme A (CoA) synthesis and expansion of intraepithelial (IEL) CD8αβ+ T cells that secrete IL-22. This epithelial-immune crosstalk potentiates ISC repair after injury, highlighting a metabolism-immune axis linking cysteine … Read more
Mucosal Immunol. 2025 Nov 17:S1933-0219(25)00125-4. doi: 10.1016/j.mucimm.2025.11.008. Online ahead of print. ABSTRACT The mucosal immune system plays a fundamental role in maintaining microbial balance. Microbial imbalance in the female genital tract increases the risk for adverse health outcomes in women and may increase susceptibility to local infections. Myeloid-derived suppressor cells (MDSCs) remain understudied in the … Read more
J Leukoc Biol. 2025 Nov 4;117(11):qiaf138. doi: 10.1093/jleuko/qiaf138. ABSTRACT Natural killer (NK) cells are the first line of defense against viral infections and tumors. Their cytotoxic activity relies on the formation of an immune synapse (IS) with target cells. The lymphocyte function-associated antigen (LFA)-1 plays a central role in NK cell cytotoxicity by modulating NK-IS … Read more
J Immunol. 2025 Nov 18:vkaf314. doi: 10.1093/jimmun/vkaf314. Online ahead of print. ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapy including immune checkpoint blockade (ICB). We previously showed that ICB selects for pancreatic tumor cells that are defective in IFN-γ-inducible MHC-I, prompting us to test the impact of IL-15 complex (IL-15C) in … Read more
Cancer Immunol Res. 2025 Nov 18. doi: 10.1158/2326-6066.CIR-25-0625. Online ahead of print. ABSTRACT The activity of bispecific antibodies against vascular endothelial growth factor (VEGF) and programmed death ligand-1 (PD-1) have reinvigorated interest in dual VEGF and PD-1 targeting across solid tumors. However, the tumor and immune features influencing tumor response remain largely unknown. We conducted … Read more
