inmunoadmin

IL-15 complex enhances therapeutic efficacy of anti-PD-L1 in a T cell-dependent and NK cell-independent manner in a murine model of pancreatic ductal adenocarcinoma

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J Immunol. 2025 Nov 18:vkaf314. doi: 10.1093/jimmun/vkaf314. Online ahead of print. ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapy including immune checkpoint blockade (ICB). We previously showed that ICB selects for pancreatic tumor cells that are defective in IFN-γ-inducible MHC-I, prompting us to test the impact of IL-15 complex (IL-15C) in … Read more

Distinct spatially resolved tumor microenvironment trajectories define benefit from ramucirumab plus pembrolizumab in refractory PD-L1+ gastric cancer

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Cancer Immunol Res. 2025 Nov 18. doi: 10.1158/2326-6066.CIR-25-0625. Online ahead of print. ABSTRACT The activity of bispecific antibodies against vascular endothelial growth factor (VEGF) and programmed death ligand-1 (PD-1) have reinvigorated interest in dual VEGF and PD-1 targeting across solid tumors. However, the tumor and immune features influencing tumor response remain largely unknown. We conducted … Read more

Myeloperoxidase transforms chromatin into an immune weapon. Hannah Garner

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Trends Immunol. 2025 Nov 17:S1471-4906(25)00284-4. doi: 10.1016/j.it.2025.11.001. Online ahead of print. ABSTRACT Burn et al. reveal a previously unrecognised, non-catalytic function of myeloperoxidase (MPO) in neutrophil extracellular trap (NET) formation; integrating super-resolution microscopy and biochemical approaches, they demonstrated that MPO’s oligomeric state governs chromatin decondensation, redefining MPO as a structural chromatin modifier with implications for … Read more

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair. Lizi M Hegarty

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Mucosal Immunol. 2025 Nov 15:S1933-0219(25)00124-2. doi: 10.1016/j.mucimm.2025.11.007. Online ahead of print. ABSTRACT Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammation and are implicated in tissue repair following injury or inflammation. Whether these roles are attributed to distinct subsets of macrophages or if macrophages retain a … Read more

Gamma-aminobutyric acid-B receptor axis promotes proliferation and survival of multiple myeloma cells via enhancing ERK1/2 activity​Wei Hu on 17 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 17:qiaf166. doi: 10.1093/jleuko/qiaf166. Online ahead of print. ABSTRACT Gamma-aminobutyric acid (GABA), a non-protein component amino acid, functions as an inhibitory neurotransmitter. Here, we showed that GABA levels are significantly elevated in the bone marrow (BM) liquid of patients with multiple myeloma (MM) compared to healthy donors (HDs). Moreover, BM GABA … Read more

Human M-MDSCs Impair Neutrophil Migration in the Infectious Microenvironment​Hannah K Weppner on 17 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 17:qiaf165. doi: 10.1093/jleuko/qiaf165. Online ahead of print. ABSTRACT Patients who survive sepsis experience a prolonged period of immunosuppression. This period is accompanied by the expansion of monocytic myeloid-derived suppressor cells (M-MDSCs), a subset of suppressive myeloid cells; however, the impact of M-MDSCs on the innate immune response to infection is … Read more

Neurological Phenotypes of SOCS1 Haploinsufficiency: Insights from Functional and Histological Investigations

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J Clin Immunol. 2025 Nov 18;45(1):165. doi: 10.1007/s10875-025-01958-z. ABSTRACT Suppressor of cytokine signaling 1 (SOCS1) haploinsufficiency is a recently described inborn error of immunity characterized by autoimmunity, inflammation, lymphoproliferation, and increased infection susceptibility. SOCS1, a negative regulator of cytokine signaling via the JAK/STAT pathway, explains the condition’s broad phenotypic variability. Single nucleotide polymorphisms in SOCS1 … Read more

The Spectrum of Bacterial Infection in a Large Cohort of Chinese Pediatric Patients with Inborn Errors of Immunity: A Nine-year, Retrospective, Single-center Study

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J Clin Immunol. 2025 Nov 18;45(1):163. doi: 10.1007/s10875-025-01964-1. ABSTRACT PURPOSE: This study aimed to investigate the spectrum of bacterial infections in children with inborn error of immunity (IEIs). METHODS: Pediatric patients with IEIs and positive for bacteria considered to be pathogenic were included in this retrospective study. RESULTS: In this study, 1811 medical records of … Read more

Evaluating Pediatric Reference Ranges for Extended Immunophenotyping from a Finnish Cohort against Published References

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J Clin Immunol. 2025 Nov 18;45(1):162. doi: 10.1007/s10875-025-01959-y. ABSTRACT Flow cytometric immunophenotyping of lymphocytes and dendritic cells, and functional lymphocyte mitogen response tests are used in the diagnostics of inborn errors of immunity (IEI), especially in pediatrics. These routinely used tests lack sufficient age-matched reference values in children. We established reference values for lymphocyte and … Read more

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