inmunoadmin Trends Immunol. 2025 Nov 13:S1471-4906(25)00268-6. doi: 10.1016/j.it.2025.10.011. Online ahead of print. ABSTRACT Recent research has shown that sequential colonization of the skin by various subsets of immune cells, particularly T cells, during perinatal stages forms layered surveillance networks crucial for maintaining skin tissue integrity and function. Here, we review our current understanding of key epigenetic … Read more
Cancer Immunol Res. 2025 Nov 14. doi: 10.1158/2326-6066.CIR-25-0454. Online ahead of print. ABSTRACT Invariant Natural Killer T (iNKT) cells are a conserved T lymphocyte population capable of acting on dendritic cells (DCs) to potently amplify downstream immune responses. However, the processes underlying such iNKT adjuvancy remain poorly understood. Here, we showed that allogeneic human CD4+ … Read more
Cancer Immunol Res. 2025 Nov 14. doi: 10.1158/2326-6066.CIR-25-0349. Online ahead of print. ABSTRACT Cellular immunotherapies show remarkable efficacy against hematological malignancies. However, applying these therapies against solid tumors is challenging. Among the obstacles are the lack of tumor-specific antigens and the immunosuppressive tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein (FAP) are key … Read more
J Leukoc Biol. 2025 Nov 14:qiaf164. doi: 10.1093/jleuko/qiaf164. Online ahead of print. ABSTRACT Following the 2025 Nobel Prize in Physiology or Medicine for the discovery of regulatory T cells (Tregs), a recent article in Nature Communications reports the creation of allogeneic, genome-edited Tregs engineered to evade immune rejection while retaining suppressive function. Through non-viral CRISPR … Read more
Mucosal Immunol. 2025 Nov 11:S1933-0219(25)00122-9. doi: 10.1016/j.mucimm.2025.11.005. Online ahead of print. ABSTRACT Identification of pathways preventing timely recovery from acute respiratory viral infection is under-studied but essential for long-term health. Using unbiased proteomics, we reveal an unexpected, reduction in lung basement membrane proteins 21 days after influenza infection when mice had symptomatically recovered. Basement membrane … Read more
J Immunol. 2025 Nov 13:vkaf299. doi: 10.1093/jimmun/vkaf299. Online ahead of print. ABSTRACT Memory stem CD8+ T cells (TSCM) are a long-lived T-cell subset with stem cell-like properties, playing a key role in antiviral immunity. Despite their importance, comprehensive single-cell transcriptomic profiling of antigen-specific TSCM has not been previously conducted. In this study, an in vitro … Read more
Cancer Immunol Res. 2025 Nov 13. doi: 10.1158/2326-6066.CIR-24-1255. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) play crucial and important role in cancer dynamics by affecting homeostasis, immunosuppression, and angiogenesis within the tumor microenvironment. Using single-cell transcriptomics, we constructed a comprehensive atlas of myeloid cell populations across healthy and pan-cancer tissues that revealed heterogeneity. Our … Read more
J Leukoc Biol. 2025 Nov 13:qiaf163. doi: 10.1093/jleuko/qiaf163. Online ahead of print. ABSTRACT Mycoplasma pneumoniae (Mp) is a frequent cause of pediatric pneumonia, largely due to the challenges in early detection and the tendency to underestimate the severity of infections. Emerging evidence suggests that ATP-binding cassette transporter G1 (ABCG1) plays a critical role in preventing … Read more
Curr Opin Immunol. 2025 Nov 11;98:102692. doi: 10.1016/j.coi.2025.102692. Online ahead of print. ABSTRACT Recent advancements in microbiome research have revealed the restorative capacities of postbiotics, including indole and its derivatives generated via bacterial tryptophan metabolism. Widespread in prokaryotic and eukaryotic communities, indole and its derivatives are uniquely suited to promote host physiology and homeostasis at … Read more
Mucosal Immunol. 2025 Nov 10:S1933-0219(25)00120-5. doi: 10.1016/j.mucimm.2025.11.003. Online ahead of print. ABSTRACT Endometrial injury triggers inflammation responses, and persistent inflammation is a recognized cause of infertility. Emerging evidence underscores the critical role of the vagus nerve in modulating immunity. Although vagotomy is known to induce systemic inflammation, the specific mechanism by which the vagus nerve … Read more
