inmunoadmin

Computational and experimental mapping of antigenic epitopes on iridovirus major capsid protein for precision vaccine design

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J Immunol. 2026 Jun 7;215(6):vkag159. doi: 10.1093/jimmun/vkag159. ABSTRACT The major capsid protein (MCP), owing to its strong immunogenicity, has emerged as a critical target for largemouth bass ranavirus (LMBV) vaccine development. However, its key antigenic epitopes remain uncharacterized. This study integrated phage display technology with bioinformatics approaches to design a multiepitope vaccine against LMBV. By … Read more

Intersection Between Systemic Autoimmune Diseases, Primary Immunodeficiency and Cancer: a Field in its Infancy

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J Clin Immunol. 2026 Jun 25. doi: 10.1007/s10875-026-02030-0. Online ahead of print. ABSTRACT PURPOSE: Systemic autoimmune diseases and primary immunodeficiencies/inborn errors of immunity (PIDs/IEIs) have traditionally been viewed as opposing immunological entities. However, growing genetic, immunological, and clinical evidence challenges this dichotomy, revealing a shared spectrum of immune dysregulation, genetic vulnerability, and convergent phenotypes. Advances … Read more

Cross-priming underlies the efficacy of antibody-drug conjugates and immunotherapy combinations. Gabriel Gomis

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Trends Immunol. 2026 Jun 24:S1471-4906(26)00155-9. doi: 10.1016/j.it.2026.06.003. Online ahead of print. ABSTRACT Antibody-drug conjugates (ADCs) selectively deliver potent chemotherapeutic agents to tumor cells. In clinical settings, the therapeutic benefits of ADCs can be improved when combined with immune checkpoint inhibitors, probably due to the immunogenic nature of ADC-induced tumor cell death, which releases tumor antigens … Read more

Pregnancy stages differentially impact maternal alveolar macrophages’ function and immunity to SARS-CoV-2 infection. Alina Fokina

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Mucosal Immunol. 2026 Jun 24:100366. doi: 10.1016/j.mucimm.2026.100366. Online ahead of print. ABSTRACT Pregnancy comes with complex immune adaptations to support the specific needs of each pregnancy stage. Infections during pregnancy pose an additional challenge in keeping the fine balance between protective and detrimental immune activation. Whether mucosal immunity adapts to different pregnancy stages is poorly … Read more

ILC2s govern imprinting of alveolar macrophage-mediated immune responses upon secondary helminth infection in the lung. Jonathan Pollock

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Mucosal Immunol. 2026 Jun 24:100367. doi: 10.1016/j.mucimm.2026.100367. Online ahead of print. ABSTRACT Hookworms migrate through the lung as part of their lifecycle, causing significant tissue damage that activates tissue-resident populations such as ILC2s. These drive type 2 immune responses critical for wound healing and the development of protective immunity. Monocyte-derived macrophages that seed the lung … Read more

A TNFR2 biparatopic antagonist reverses immune suppression through a crosslinking-resistant and ADCC- independent mechanism​Shusu Liu on 24 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 24:qiag086. doi: 10.1093/jleuko/qiag086. Online ahead of print. ABSTRACT Tumor necrosis factor receptor 2 (TNFR2) is a promising immunotherapeutic target due to its high upregulation on immunosuppressive populations, like regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). The clinical efficacy of conventional bivalent TNFR2 antagonists, such as BI1808, is fundamentally … Read more

Induction of Humoral and Cellular Immunity After SARS‐CoV‐2 JN.1 Vaccination in Individuals With and Without Prior Infection. [[{“value”:”Caroline Diener, Rebecca Urschel, Saskia Bronder, Candida Guckelmus, Johannes Eckel, Franziska Hielscher, Denisa Bojkova, Sandra Ciesek, Marek Widera, Tina Schmidt, Martina Sester”}]]

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JN.1 vaccination induced strong, cross-reactive CD4 and CD8 T-cell responses and markedly boosted neutralizing antibodies, especially against omicron variants. Influenza vaccine coadministration did not impair immunogenicity. Prior SARS-CoV-2 infection was associated with higher baseline and postvaccine neutralizing activity, while cellular responses remained unaffected by infection history. ABSTRACT The continuous evolution of SARS-CoV-2 raises concerns about … Read more

Decoding the complexity of intestinal immunity with spatial transcriptomics

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Curr Opin Immunol. 2026 Jun 23;101:102806. doi: 10.1016/j.coi.2026.102806. Online ahead of print. ABSTRACT The intestine integrates nutrient digestion and absorption with immune surveillance, being continuously challenged by dietary antigens, commensal microbiota, and pathogens. Its highly regionalized structure requires the immune system to balance tolerance to food and commensal organisms with protective responses against pathogens, generating … Read more

High CD163+CD206+macrophages infiltration in the bone marrow microenvironment of newly diagnosed multiple myeloma patients​Dong-Hai Han on 23 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 23:qiag076. doi: 10.1093/jleuko/qiag076. Online ahead of print. ABSTRACT Multiple myeloma (MM) is a neoplastic disease caused by abnormal clonal plasma cells (PCs) in the bone marrow (BM). Macrophages(MФs) are essential components of BM microenvironment and crucial mediators of PCs. Therefore, investigating alterations in the specific MФ subsets within the MM … Read more

Gut microbiome metabolites meet immunometabolism in inflammatory bowel disease. Qing Li

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Trends Immunol. 2026 Jun 23:S1471-4906(26)00138-9. doi: 10.1016/j.it.2026.06.001. Online ahead of print. ABSTRACT Growing evidence indicates that gut microbiota-derived metabolites are key regulators of immunometabolism in inflammatory bowel disease (IBD). Intestinal epithelial cells and immune cells exhibit profound metabolic alterations in IBD. Microbial metabolites act as intermediates in host-microbe communication, reshaping mitochondrial functions and cellular metabolic … Read more

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