inmunoadmin

Variable fab domain N-glycosylation patterns in the B cell receptor repertoires of healthy individuals and patients with rheumatoid arthritis

by

J Immunol. 2026 Jun 7;215(6):vkag113. doi: 10.1093/jimmun/vkag113. ABSTRACT N-linked glycosylation (N-glyc) sites (N-X-S/T, X≠P) can be introduced by somatic hypermutation in immunoglobulin Fab regions. In patients with rheumatoid arthritis (RA), anti-citrullinated protein antibodies have a striking overrepresentation of Fab N-glycosylation. To further explore this, we sequenced B cell receptors (BCRs) from peripheral blood of 13 … Read more

BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation

by

J Immunol. 2026 Jun 7;215(6):vkag101. doi: 10.1093/jimmun/vkag101. ABSTRACT Efficient tissue regeneration requires the precise coordination of inflammatory and regenerative programs, principally mediated by monocyte-derived macrophages. However, the transcriptional wiring and epigenomic processes behind complex macrophage subtype specification and transition between the different states are not known. Here we have identified the transcriptional repressor BACH1 as … Read more

Multiple Myeloma Cells Resistant to T-cell Therapies Exhibits a CD45+ Immune Evasive Phenotype

by

Cancer Immunol Res. 2026 Jun 10. doi: 10.1158/2326-6066.CIR-25-1068. Online ahead of print. ABSTRACT Multiple myeloma (MM) is plasma cell malignancy that is mostly incurable, even with recent advances in treatment such as BCMA-targeted chimeric antigen receptor (CAR) T cells and bispecific T cell-engaging antibodies (TCEs). To better understand this treatment resistance, we examined MM cells … Read more

Bioelectric signaling as an emerging layer of macrophage communication. Weijia Zheng

by

Trends Immunol. 2026 Jun 10:S1471-4906(26)00130-4. doi: 10.1016/j.it.2026.05.005. Online ahead of print. ABSTRACT Bioelectric signaling may represent an emerging layer of macrophage communication. This forum discusses how membrane-potential dynamics, ion fluxes, and context-dependent intercellular coupling may coordinate macrophage responses within tissues, highlighting a potential new dimension of immune regulation with broad implications for tissue-level immunity. PMID:42270522 … Read more

CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells

by

J Immunol. 2026 Jun 7;215(6):vkag110. doi: 10.1093/jimmun/vkag110. ABSTRACT The cytokines interleukin (IL)-22 and IL-17 are secreted by innate and adaptive immune cells to drive “type III” responses that protect against extracellular pathogens, promote mucosal barrier integrity, and foster microbiota homeostasis. However, dysregulation of IL-22 and/or IL-17 contributes to autoimmunity, chronic inflammation, and malignancy. Thus, a … Read more

Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages​Sebastien Jacquelin on 10 de June de 2026 at 10:00

by

J Leukoc Biol. 2026 Jun 10:qiag074. doi: 10.1093/jleuko/qiag074. Online ahead of print. ABSTRACT The proliferation, differentiation and survival of cells of the macrophage lineage depends on signals from the macrophage colony-stimulating factor receptor (CSF1R). On a C57BL/6J background homozygous kinase-dead Csf1r mutation (Csf1rE631K/E631K – E631Km/m) causes perinatal lethality. By contrast, E631Km/m mice on a mixed … Read more

Carboxylesterase 1 contributes to the human macrophage alternative activation response to Th2 cytokine interleukin-4​Matthew K Ross on 10 de June de 2026 at 10:00

by

J Leukoc Biol. 2026 Jun 10:qiag073. doi: 10.1093/jleuko/qiag073. Online ahead of print. ABSTRACT Carboxylesterase 1 (CES1) is a hydrolytic enzyme with roles in xenobiotic and lipid metabolism. Our previous studies suggested a novel role for CES1 in the regulation of macrophage gene expression following exposure to inflammatory molecules. The nuclear receptor PPARγ has an important … Read more

Promoting intestinal regeneration without tumor risk in immune-mediated inflammatory diseases. Angélica Díaz-Basabe

by

Trends Immunol. 2026 Jun 9:S1471-4906(26)00129-8. doi: 10.1016/j.it.2026.05.004. Online ahead of print. ABSTRACT Immune-mediated inflammatory disorders, such as inflammatory bowel diseases, are characterized by chronic inflammation and damage to the intestinal barrier. Several of the current therapeutic strategies for inflammatory diseases attempt to decrease inflammation but cause side effects in a significant fraction of patients without … Read more

DNA sensing and regulation of lipid metabolism. Soumyabrata Guha

by

Trends Immunol. 2026 Jun 9:S1471-4906(26)00131-6. doi: 10.1016/j.it.2026.05.006. Online ahead of print. ABSTRACT Immunity and metabolism are deeply intertwined in maintaining homeostasis. With the recognition of cytosolic dsDNA sensing as an initiator of immune responses, its interface with metabolic rewiring has emerged as a key area of investigation. Focusing on the stimulator of interferon genes adaptor … Read more

A pancreatic intraepithelial neoplasia-Oramic view of early pancreatic cancer in 3D. Alexander Cicala

by

Trends Immunol. 2026 Jun 9:S1471-4906(26)00132-8. doi: 10.1016/j.it.2026.05.007. Online ahead of print. ABSTRACT Pancreatic cancer is a deadly disease defined by an immunosuppressive microenvironment refractory to therapy. Kiemen et al. applied 3D histology, imaging mass cytometry, and spatially resolved DNA sequencing to human pancreata containing early precursors of the disease, revealing heterogeneous and mutation-specific inflammatory niches … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri cURL Hatası: Could not resolve host: lkl.dolarkurum.com