inmunoadmin

Stable β2‐Microglobulin–HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer‐Associated Epitopes. [[{“value”:”Ana Barajas Molina, Yehor Horokhovskyi, Nicole Acuti, Yee Kien Chong, Meghna Phanichkrivalkosil, Sophie Siddons, Hassnae Afrache, Megan Maloney, Wai Tuck Soh, Tom Hofland, Callum Hall, Henning Urlaub, George Kassiotis, Juliane Liepe, Michele Mishto”}]]

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We investigated differences in peptide repertoire when β2-microglobulin is fused to the HLA-I heavy chain. We observed: (1) that immunopeptidomes changed in this condition, (2) an overall increased median IC50 of the entire peptide repertoire, and (3) a reduced presentation of cancer-specific epitopes with a strong predicted binding affinity for HLA-I. ABSTRACT β2-Microglobulin (β2m) is … Read more

When the lung is at risk: diagnosis, manifestations, and complications of pulmonary sarcoidosis

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Curr Opin Immunol. 2026 May 27;101:102792. doi: 10.1016/j.coi.2026.102792. Online ahead of print. ABSTRACT Sarcoidosis is a heterogeneous granulomatous disease of unknown origin; a subset of patients develops an advanced pulmonary disease phenotype, marked by progressive pulmonary fibrosis, airway involvement, and sarcoidosis-associated pulmonary hypertension, leading to high morbidity and mortality. In this review, we summarize key … Read more

Beyond Suppression: The Plasticity, Dysfunction, and Therapeutic Reprogramming of Regulatory T Cells in Inflammatory Bowel Disease​Yunting Shao on 27 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 28:qiag067. doi: 10.1093/jleuko/qiag067. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gut, whose pathogenesis is closely related to immune dysregulation. Regulatory T cells (Tregs), as a key cell population maintaining intestinal immune tolerance, exhibit not only reduced frequency but, more critically, … Read more

Human antibodies as emerging drugs for antimicrobial resistance. Matteo Ridelfi

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Trends Immunol. 2026 May 27:S1471-4906(26)00096-7. doi: 10.1016/j.it.2026.04.003. Online ahead of print. ABSTRACT Antimicrobial resistance (AMR) is one of today’s most worrisome health emergencies. Bacteria, once easily treatable with antibiotics, have acquired resistance to many or all available drugs. In 2019, 1.27 million infection-related deaths were directly caused by AMR. By 2050, AMR could put 10 … Read more

CNS1-dependent regulatory T cells shape recovery from acute lung injury

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J Immunol. 2026 May 14;215(5):vkag119. doi: 10.1093/jimmun/vkag119. ABSTRACT Regulatory T cells (Tregs) play a crucial role in mediating recovery from acute lung injury (ALI). However, the complex roles of functionally heterogeneous Treg subsets in the lung during the resolution of acute inflammation remain unclear. To investigate the role of peripherally induced Tregs, we utilized mice … Read more

miR-378b-3p promotes porcine reproductive and respiratory syndrome virus replication by negatively regulating type I interferon expression via targeting OGT

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J Immunol. 2026 May 14;215(5):vkag121. doi: 10.1093/jimmun/vkag121. ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viral pathogens for the swine industry. PRRSV has evolved diverse strategies to modulate the type I interferon (IFN-I) response during infections. Recently, it has become increasingly recognized that microRNAs (miRNAs) can contribute to … Read more

Withania somnifera extracts and withaferin A differentially regulate neutrophil pyroptosis, NETosis, and apoptosis​Partha Sarathi Mondal on 26 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 13;118(5):qiag049. doi: 10.1093/jleuko/qiag049. ABSTRACT Neutrophils are short-lived, yet critical components of the innate immune system. These cells play crucial roles in host defense and inflammation. Their high turnover during inflammatory responses is often accompanied by inflammatory lytic cell death, such as NETosis and pyroptosis, which can amplify tissue damage. Thus, … Read more

Pregnancy-induced NK cells of importance to gravidity and preeclampsia

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J Immunol. 2026 May 14;215(5):vkag027. doi: 10.1093/jimmun/vkag027. ABSTRACT Immunological changes induced by a woman’s first pregnancy in controls and in cases of preeclampsia, which is more frequent and often a more severe complication in primigravid women, were investigated. Decidual natural killer (NK) cells are important for placentation and interact with HLA Ib molecules on extravillous … Read more

Myeloid cell IL-15 production in the brain supports bystander CD8+ T cell neuropathic immune responses following virus infection

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J Immunol. 2026 May 14;215(5):vkag102. doi: 10.1093/jimmun/vkag102. ABSTRACT The central nervous system (CNS) includes a uniquely regulated immune response that supports homeostasis, response to injury, and response to pathogens. Recent work has shown that virus-associated immune responses in the CNS may contribute to neuronal injury and long-term outcomes such as neurocognitive decline. However, the fundamental … Read more

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