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Transforming Growth Factor Beta/Smad3/GATA3 Axis Mediates the Therapeutic Effect of Ephedra sinica Stapf Polysaccharide in Allergic Rhinitis​Jingfei Zhang on 25 de February de 2026 at 11:00

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J Leukoc Biol. 2026 Feb 25:qiag023. doi: 10.1093/jleuko/qiag023. Online ahead of print. ABSTRACT Allergic rhinitis (AR) is a prevalent inflammatory disorder with limited therapeutic options. Ephedra sinica Stapf (ESP), a traditional Chinese herb, has shown potential in respiratory diseases, but its bioactive components and mechanisms remain unclear. This study investigates the anti-inflammatory effects of ESP-B4, … Read more

VSIG4 restricts hepatocellular carcinoma control by suppressing tumor-specific CD8+ T cell immunity in the tumor microenvironment

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Cancer Immunol Res. 2026 Feb 25. doi: 10.1158/2326-6066.CIR-25-0836. Online ahead of print. ABSTRACT Immunotherapies have revolutionized the treatment of hepatocellular carcinoma (HCC), yet their response rates remain limited, highlighting the need for new therapeutic targets. In this study, we found that VSIG4 (V-set and immunoglobulin domain containing 4) is predominantly expressed by macrophages in both … Read more

Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology. [[{“value”:”Isabel San Martín Molina, Hanneke Okkenhaug, Simon Walker, Michelle Linterman, Edith Marcial‐Juárez”}]]

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We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, automated cyclic imaging, image preprocessing, and a new analysis method that detects morphological changes in irregularly shaped stromal cells.

Type 1 and CD103+ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn’s Disease. [[{“value”:”Elisa Arribas‐Rodríguez, Carolina G. de Castro, Aida Fiz‐López, Ángel De Prado, Álvaro Martín‐Muñoz, Luis Fernández Salazar, Jesús Barrio, Sandra Izquierdo, Javier García Alonso, Beatriz de Andrés, José María García‐Abril, Alejandro Romero, Javier Sánchez González, Cecilio Santander, Eduardo Arranz, María Chaparro, José A. Garrote, Javier P. Gisbert, David Bernardo”}]]

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Human lamina propia mononuclear cells (LPMC) were isolated from intestinal biopsies and resections, as well as peripheral blood mononuclear cells (PBMC) from blood. Using flow cytometry approaches, we characterized cDC subsets and assessed their functional capacity through T-cell coculture assays (after isolation of the different subsets of cDC using sorter cytometry). This approach enabled a … Read more

Engineered CCR7 overexpression enhances nodal CAR-T cell homing and cytotoxicity toward B cell lymphoma

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Cancer Immunol Res. 2026 Feb 24. doi: 10.1158/2326-6066.CIR-25-1381. Online ahead of print. ABSTRACT Anti-CD19 chimeric antigen receptor (CAR) therapy demonstrated remarkable efficacy against hematological malignancies. However, B cell malignancies with lymph node (LN) involvement frequently remain resistant. Here, we show that CAR T cells downregulated the chemokine receptor CCR7, crucial for nodal homing, during manufacturing. … Read more

Dickkopf1 is a novel endogenous ligand for priming NLRP3 inflammasome in macrophages via TLR4

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J Immunol. 2026 Feb 9;215(2):vkaf367. doi: 10.1093/jimmun/vkaf367. ABSTRACT Dickkopf1 (DKK1) is a quintessential Wnt antagonist and immunomodulator in various inflammatory diseases. The underlying molecular mechanisms of DKK1-mediated immunomodulation remain elusive. Here, we identified TLR4 as a new receptor for DKK1, activating NFκB-mediated gene expression. Subsequently, this event resulted in pyroptosis via the NLRP3 inflammasome in … Read more

Membrane atg8ylation and autophagy in protection against Mycobacterium tuberculosis

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J Immunol. 2026 Feb 9;215(2):vkaf359. doi: 10.1093/jimmun/vkaf359. ABSTRACT Membrane atg8ylation is a broad homeostatic process of immunological import. It encompasses membrane repair and remodeling pathways, including canonical autophagy, in cells subjected to stress, damage, infection, and immune or metabolic signaling under microbe-induced or sterile inflammatory conditions. The initial reports on autophagy, which is one of … Read more

CD4+ T‐Cell‐Intrinsic IL‐6 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell‐Mediated Suppression. [[{“value”:”Chakrapani Vemulawada, Kshitija Kale, Michael P. Crawford, Nitin J. Karandikar”}]]

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1. Normal state: T-cell-endogenous IL-6 stabilizes IL6R and promotes STAT3 activation, functional Th17 differentiation with resistance to immune suppression. 2. Il6-KO: Loss of T-cell endogenous IL-6 destabilizes IL6R expression, leading to suboptimal Th17 and greater susceptibility to suppression, despite availability of exogenous IL-6. 3. IL-21 bypasses the requirement for endogenous IL-6 by restoring STAT3 signaling … Read more

Alveolar macrophages shape tuberculosis susceptibility by delaying protective immunity. Consuelo Micheli

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Mucosal Immunol. 2026 Feb 21:S1933-0219(26)00023-1. doi: 10.1016/j.mucimm.2026.02.006. Online ahead of print. ABSTRACT EFFECTIVE control of Mycobacterium tuberculosis (Mtb) infection requires timely activation and accumulation of CD4+ T cells in the lungs, yet the factors delaying this response remain unclear. Here we show that alveolar macrophages (AMs) delay CD4+ T cell priming by retaining Mtb within … Read more

Interaction between airway basal cells, mast cells and type 2 immunity contributes to epithelial barrier dysfunction in allergic rhinitis. Emma Ruysseveldt

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Mucosal Immunol. 2026 Feb 21:S1933-0219(26)00021-8. doi: 10.1016/j.mucimm.2026.02.004. Online ahead of print. ABSTRACT Basal cell dysfunction contributes to the pathophysiology of chronic inflammatory airway disorders and is linked to persistent epithelial barrier defects. Epithelial integrity dysfunction, basal cell hyperplasia and metaplasia have been described in allergic rhinitis (AR). However, it remains unclear how basal cell progenitor … Read more

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