inmunoadmin

H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability​Heidi Rysan on 6 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 5:qiag001. doi: 10.1093/jleuko/qiag001. Online ahead of print. ABSTRACT IKZF3/Aiolos is a zinc-finger transcriptional transcription factor that functions as a transcriptional repressor in B cell development. IKZF3 mutations are associated with human diseases including immunodeficiency, leukemia and lymphoma. H195Y IKZF3 mutation was discovered in a mouse model of precursor B cell … Read more

TNFR2-targeting biologics: Molecular mode of action, possible applications and future developments​Olena Zaitseva on 6 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 5:qiag002. doi: 10.1093/jleuko/qiag002. Online ahead of print. ABSTRACT Tumor necrosis factor-α (TNF) and its receptors have emerged as key players in autoimmunity but also influence tumor development and the tumor microenvironment in many ways. TNF-inhibiting biologics are used very successfully in the clinic to treat autoimmune diseases. However, in some … Read more

Multidimensional Assessment of Patient-Reported-Outcomes in a Multicenter Cohort of Inborn Errors of Immunity

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J Clin Immunol. 2026 Jan 6. doi: 10.1007/s10875-025-01972-1. Online ahead of print. ABSTRACT Patient-reported outcomes are critical to multidisciplinary, patient-centred approaches in diseases requiring lifelong management. Among inborn errors of immunity (IEIs), reports on this subject are typically limited to specific diagnostic subgroups or focus narrowly on the route of immunoglobulin replacement therapy (IgRT), offering … Read more

Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis. [[{“value”:”Megan M. Hanlon, Ursula Fearon, Ellen M. Gravallese”}]]

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Synovial tissue macrophages are essential coordinators of joint homeostasis and inflammatory responses in rheumatoid arthritis. Here, we highlight recent advances that have enabled a deeper characterization of synovial tissue macrophages and their distinct phenotypes and functions in health and disease. ABSTRACT Synovial tissue macrophages are critical orchestrators in the pathogenesis of rheumatoid arthritis, comprising a … Read more

Cover Story: Eur. J. Immunol. 1’26.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Interleukin-23 biology linking mucosal immunity to autoimmune diseases and cancer. Anees Ahmed

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Trends Immunol. 2026 Jan 3:S1471-4906(25)00313-8. doi: 10.1016/j.it.2025.12.005. Online ahead of print. ABSTRACT Interleukin-23 (IL-23) is a pleiotropic cytokine that maintains the delicate balance between tolerance to commensal microbiota and defense against pathogens at mucosal barriers. When dysregulated, IL-23 becomes a key driver of chronic inflammation, with therapeutics blocking this pathway being successfully harnessed in the … Read more

TNFRSF13B Variant-Induced TACI Dysregulation Underlies CAEBV Pathogenesis

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J Clin Immunol. 2026 Jan 2. doi: 10.1007/s10875-025-01973-0. Online ahead of print. ABSTRACT The tumor necrosis factor (TNF) receptor superfamily member, transmembrane activator and CAML interactor (TACI) encoded by TNFRSF13B, are extensively involved in immune responses. In our previous work, TNFRSF13B exon 2 variants were recurrently identified in chronic active Epstein-Barr virus disease (CAEBV). Here … Read more

Characterizing immune cell profiles of patients with rheumatoid arthritis in Taiwan using artificial intelligence-based cytometric approaches​Po-Yu Li on 1 de January de 2026 at 11:00

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J Leukoc Biol. 2026 Jan 2:qiaf188. doi: 10.1093/jleuko/qiaf188. Online ahead of print. ABSTRACT Changes in specific immune cell lineages, such as T and B cells, play a central role in the pathogenesis of rheumatoid arthritis (RA). However, a comprehensive evaluation of systemic immune cell changes in RA remains limited. Immune cell proportions of 104 subsets … Read more

Single-cell transcriptome analysis reveals the association between ketone body synthesis and morphogenic profile of intestinal epithelia in neonatal mice. Kyoko Matsuki

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Mucosal Immunol. 2025 Dec 30:S1933-0219(25)00141-2. doi: 10.1016/j.mucimm.2025.12.005. Online ahead of print. ABSTRACT The intestinal epithelium undergoes robust maturation postnatally, yet its early-life characteristics remain poorly understood. Using single-cell RNA sequencing, we analyzed intestinal epithelial cells from neonatal (10-day-old) and juvenile (21-day-old) mice reared under both specific pathogen-free and germ-free conditions. Among the various cell types … Read more

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