inmunoadmin

Transient alterations in nucleosome distribution and sensitivity to nuclease define the THP-1 monocyte-to-macrophage transition​Jane M Benoit on 1 de October de 2025 at 10:00

by

J Leukoc Biol. 2025 Oct 1;117(10):qiaf062. doi: 10.1093/jleuko/qiaf062. ABSTRACT The monocyte-to-macrophage transition is marked by alterations to both the structure and function of the genome, including changes in histone posttranslational modifications, DNA methylation, 3D nuclear architecture, and expression of lineage specific genes. The nucleosome is the fundamental organizational unit of the eukaryotic genome and underpins … Read more

Dynamic nucleosome redistribution and increases in nucleosome sensitivity underpin THP-1 macrophage response to LPS​Jane M Benoit on 1 de October de 2025 at 10:00

by

J Leukoc Biol. 2025 Oct 1;117(10):qiaf067. doi: 10.1093/jleuko/qiaf067. ABSTRACT Macrophages detect lipopolysaccharide (LPS) through toll-like receptor 4 (TLR-4) on the cell surface which initiates a signaling cascade, resulting in the recruitment of regulatory factors to chromatin and subsequent expression of chemokine and cytokine genes. Primary response genes, marked by poised promoters and enhancers, are rapidly … Read more

The Targets of Immune Adverse Events in Cancer Immunotherapy by Combined Check-point Inhibitors Resemble those Seen in IPEX Patients

by

J Clin Immunol. 2025 Oct 1;45(1):141. doi: 10.1007/s10875-025-01929-4. ABSTRACT INTRODUCTION: Specific determinants of target-organ damage in autoimmune diseases are complex and multifactorial, several genetic and environmental factors are recognized but mostly remain unknown. Immunotherapy with “check-point inhibitors” (CPI) is complicated by immune related adverse events (IRAE), occurring in a large fraction of patients, with organ-specific … Read more

Kupffer cells facilitate intrahepatic CD4 T cell help. Tobias Boettler

by

Trends Immunol. 2025 Sep 29:S1471-4906(25)00223-6. doi: 10.1016/j.it.2025.09.004. Online ahead of print. ABSTRACT Intrahepatic immune responses are often insufficient to control hepatitis virus infections. A recent study by Venzin and colleagues demonstrates a detailed mechanism by which an intrahepatic tricellular network and the cytokine IL-27 can augment virus-specific immunity. PMID:41027760 | DOI:10.1016/j.it.2025.09.004

Latest insights into oncolytic viro-immunotherapy with vesicular stomatitis virus. Manuela Lizarralde-Guerrero

by

Semin Immunol. 2025 Sep 29;80:101996. doi: 10.1016/j.smim.2025.101996. Online ahead of print. ABSTRACT Vesicular stomatitis virus (VSV), a rhabdovirus with intrinsic oncolytic properties, has emerged as a promising candidate for cancer therapy. Thanks to impaired antiviral responses affecting cancer cells, particularly downregulated type I interferon signaling, VSV selectively replicates in tumor cells while sparing normal cells. … Read more

Tissue damage, myocardial injury and recruitment of mature and banded neutrophils after high-intensity endurance exercise​Bernard N Jukema on 30 de September de 2025 at 10:00

by

J Leukoc Biol. 2025 Sep 30:qiaf137. doi: 10.1093/jleuko/qiaf137. Online ahead of print. ABSTRACT Neutrophils are key players in inflammatory responses that are modulated by cytokines/chemokines and damage associated molecular patterns (DAMPs). Exercise induces acute neutrophilia, but little is known regarding recruitment of neutrophil subsets (banded (CD16dim/CD62Lbright) and hypersegmented (CD16bright/CD62Ldim) cells) and it’s relation with the … Read more

CD4+ T cells mediate MHC-deficient tumor rejection and endothelial cell reprogramming

by

Cancer Immunol Res. 2025 Sep 30. doi: 10.1158/2326-6066.CIR-24-1342. Online ahead of print. ABSTRACT Low or absent expression of major histocompatibility complex (MHC) on tumor cells is a presumed mechanism of resistance to immunotherapy, but evidence for this has largely been indirect. Likewise, whether immunotherapy can be effective without tumor MHC expression is also poorly understood. … Read more

Gastrointestinal MAIT cells in chronic HIV-1 infection

by

J Immunol. 2025 Sep 30:vkaf266. doi: 10.1093/jimmun/vkaf266. Online ahead of print. ABSTRACT Mucosa-associated invariant T (MAIT) cells are innate-like T cells abundant in mucosal tissues, liver, and blood. MAIT cells recognize riboflavin metabolite-derived microbial antigens displayed by the MHC-I-related protein (MR1) and respond by producing cytokines, killing infected cells, and suppressing microbial growth. We previously … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri