inmunoadmin

Diet-derived microbial metabolites as regulators of immune function

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Curr Opin Immunol. 2025 Dec 22;98:102713. doi: 10.1016/j.coi.2025.102713. Online ahead of print. ABSTRACT The intestinal microbiota transforms dietary components into bioactive metabolites that profoundly influence mucosal and systemic immunity. Short-chain fatty acids, secondary bile acids and tryptophan-derived indoles are among the most studied microbial metabolites shaping T, B and innate immune cell functions through a … Read more

The gut-liver axis modulates intestinal immune homeostasis. Yang Gu

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Mucosal Immunol. 2025 Dec 21:S1933-0219(25)00137-0. doi: 10.1016/j.mucimm.2025.12.001. Online ahead of print. ABSTRACT The intestine and liver are physically interconnected through the biliary system, portal circulation, lymphatic network, and neural pathways, collectively forming the gut-liver axis. The gut-liver axis and the immune system are engaged in a complex regulatory relationship. Over the past few decades, significant … Read more

MDA5-MAVS and interferon-lambda signaling in the intestinal epithelium limit murine astrovirus infection. Heyde Makimaa

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Mucosal Immunol. 2025 Dec 21:S1933-0219(25)00138-2. doi: 10.1016/j.mucimm.2025.12.002. Online ahead of print. ABSTRACT Human astroviruses (HAstVs) are a global cause of pediatric gastroenteritis and can cause disseminated infection in immunocompromised hosts. Murine astrovirus (muAstV) causes acute asymptomatic infections in immunocompetent mice and chronic infection in immunodeficient models and has provided important insights into AstV pathogenesis in … Read more

IL-36 mediates immune activation in Sjögren’s disease and may represent a novel biomarker of disease​Bayan Alhaddad on 23 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 22:qiaf183. doi: 10.1093/jleuko/qiaf183. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a systemic autoimmune disease. The underlying disease mechanisms remain poorly understood and there are no curative therapies. MyD88-mediated signaling is essential for SjD, although the pathways that rely on MyD88 are not well characterized. Our objective was to … Read more

Regulation of intestinal regulatory T cells via stress response pathways in inflammatory bowel disease. Kibrom M. Alula Tom T. Nguyen Edwin F. de Zoeten a Mucosal Inflammation Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USAb Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

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Volume 59, Issue 1, December 2026.

Signatures of Trained Immunity Following mRNA Vaccination: Differences Between mRNA-1273 and BNT162b2

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J Clin Immunol. 2025 Dec 24. doi: 10.1007/s10875-025-01977-w. Online ahead of print. ABSTRACT Trained immunity, a de-facto innate immune memory, has been extensively studied in response to live-attenuated vaccines, but its presence following the new COVID-19 vaccines has not yet been fully elucidated. In this study, we investigate markers of trained immunity in individuals vaccinated … Read more

Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation. [[{“value”:”Thorge Dobbertin, Lucas Schirmer”}]]

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This review summarizes emerging spatially resolved multi-omics approaches revealing organized cell–cell interactions in skeletal muscle and brain inflammation. These tools uncover radiating molecular programs and niche-specific immunopathology that shape cellular reactivity and vulnerability. ABSTRACT Spatial omics technologies enable high-resolution mapping of transcriptomic, proteomic, and metabolic profiles within intact tissues, revealing how immune, stromal, and parenchymal … Read more

Negative regulation of a new collectin-11/calreticulin-mediated NF-κB pathway by miR-194b-3p in antibacterial immunity of Takifugu obscurus

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J Immunol. 2025 Dec 22:vkaf319. doi: 10.1093/jimmun/vkaf319. Online ahead of print. ABSTRACT The innate immune system of teleost fish, such as Takifugu obscurus, depends on pattern recognition receptors to detect microbes and mount immune responses. In this study, a new collectin gene was identified in T. obscurus, designated ToCL-11. The full-length cDNA of ToCL-11 encodes … Read more

The trilateral nexus of autoimmune thyroiditis: integrating immunological triggers, endocrine disruption, and gut microbiome alterations for treatment strategies. Xiangkun Meng Rui Hao Ke Liu Pei Zhang Cheng An Ying Zhang Hongjiao Li Bangtai Wu Min Li Xiaotong Yu Xiaolin Tong a College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Chinab Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Chinac Department of Endocrinology, South Branch of Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Chinad Beijing University of Chinese Medicine, Beijing, Chinae Institute of Clinical Basic Medicine, China Academy of Chinese Medical Sciences, Beijing, Chinaf Shantou Hospital of Traditional Chinese Medicine, Shantou, China

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Volume 59, Issue 1, December 2026.

Targeting γδ T cells for immunotherapies against colorectal cancer. Joanna Mikulak

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Trends Immunol. 2025 Dec 20:S1471-4906(25)00308-4. doi: 10.1016/j.it.2025.11.009. Online ahead of print. ABSTRACT The advancement of immunotherapy faces significant challenges, including extending its benefits to a growing number of patients and enhancing its efficacy across different tumor types. In this context, γδ T cells emerge as particularly promising candidates owing to their distinctive biological features such … Read more

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