Publicaciones

Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A

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J Immunol. 2026 Jul 10;215(7):vkag194. doi: 10.1093/jimmun/vkag194. ABSTRACT The TNF‑like cytokine TL1A is a key regulator of immune responses through engagement of its receptor, death receptor 3 (DR3), and has emerged as a therapeutic target in inflammatory diseases. Prevailing models propose that TL1A binding initiates recruitment of adaptor proteins to DR3, leading to downstream signaling. … Read more

CXCR2-mediated metabolic interaction between prostate cancer cells and the immunosuppressive tumor microenvironment

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Background
Neuroendocrine prostate cancer (NEPC) is characterized by strong immune evasion and profound metabolic reprogramming. A high regulatory T cell (Treg)/CD8+ T cell ratio and an increased proportion of M2/M1 tumor-associated macrophages (TAMs)…

Complete response to dual immune checkpoint blockade in a patient with Birt-Hogg-Dube syndrome and epithelioid angiomyolipoma

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Epithelioid angiomyolipoma (E-AML) is a rare renal tumor, which can exhibit malignant potential. Because angiomyolipomas frequently harbor TSC1/TSC2 alterations, mTOR inhibitors are commonly used. However, durable disease control remains inconsistent….

Multi-omic characterization of 14q deletion in renal clear cell carcinoma identifies EDNRB as a predictor of immunotherapy response

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Background
Although chromosome 14q deletion (14q–) is present in up to 40% of clear cell renal cell carcinoma (ccRCC) cases, its immunologic and molecular impact remains unclear. Because TRAF3 and NFKBIA, key regulators of nuclear factor kappa-l…

Clinical determinants of survival outcomes and acute toxicity after adoptive cellular therapy for solid tumors

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BackgroundThe efficacy of cellular therapies has been demonstrated in hematologic malignancies, and their use is expanding to solid tumors. Predictors of outcomes and toxicities remain limited in patients undergoing cellular therapies for solid tumors….

Soluble immune checkpoints in lung cancer: linking prognostic signatures to immunotherapy response – a meta-analysis

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IntroductionNon-small cell lung cancer (NSCLC) remains one of the leading causes of cancer-related death, with most patients diagnosed at advanced, unresectable stages. Although immune-checkpoint inhibitors have transformed the therapeutic landscape, o…

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