Atopic dermatitis is a chronic inflammatory skin disease influenced by genetic predisposition, immune dysregulation, and environmental factors, as well as skin and gut microbiota. This review summarises the key mechanisms involved in this disease devel…
BackgroundIntrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with poor prognosis and limited treatment options. Disulfidptosis, a novel cell death pathway driven by disulfide bond accumulation, has emerged as a potential mechanism in can…
Oral squamous cell carcinoma (OSCC) is an aggressive malignancy with a profoundly immunosuppressive tumor microenvironment and persistently poor responses to immune checkpoint inhibitors. Recent evidence highlights dysregulated iron metabolism as a cri…
BackgroundChronic spontaneous urticaria (CSU) is a heterogeneous immune-mediated disorder characterized by recurrent wheals and/or angioedema. Despite advances in understanding its pathogenesis, robust biomarkers for disease stratification remain lacki…
Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation accompanied by pathological angiogenesis, which contributes to pannus formation and disease progression. However, the upstream mechanisms regulating pathological angiogenesis i…
BackgroundAdenoid hypertrophy (AH) frequently coexists with allergic rhinitis (AR) in children, yet the molecular mechanisms underlying this comorbidity remain unclear. Using nasopharyngeal swab-based transcriptomics—enabling inclusion of healthy pedia…
ObjectiveTo compare efficacy, survival and tumor immune microenvironment between neoadjuvant chemoradiotherapy (NCRT) and neoadjuvant immunochemotherapy (NICT) in patients with esophageal squamous cell carcinoma (ESCC) to guide individualized treatment…
IntroductionSplenocytes are important for various applications in medicine and biotechnology, but isolation methods are often limited by low yield, poor viability, bias towards certain cell subtypes, and degradation of surface marker expression. Here, …
BackgroundImmune checkpoint inhibitor (ICI)–related overlap syndrome involving myositis, myocarditis, and myasthenia gravis (3M overlap syndrome) is rare but potentially fatal. Current evidence is derived mainly from case reports and small case series,…
IntroductionFibroblast activation protein (FAP)-targeted radiopharmaceuticals have been widely applied in oncologic imaging and therapy, while their application in pulmonary fibrosis remains underexplored. This study investigated the biodistribution an…
