IntroductionMany environmental materials can activate macrophages and trigger inflammatory responses. However, whether and how these exposures alter macrophage function in host defense remains elusive.MethodsBone marrow-derived macrophages were treated…
BackgroundMechanical stimulation is a key biomechanical characteristic of the tumor microenvironment and is involved in tumor progression, immune microenvironment remodeling, and therapy resistance. This study aimed to develop a mechanical stimulation-…
Clinical outcomes in hypertriglyceridemia-associated acute pancreatitis remain highly heterogeneous. Despite comparable lipid burdens, patients may experience anything from mild interstitial edema to fulminant necrotizing disease, a divergence that cur…
BackgroundColorectal cancer liver metastasis (CRLM) develops within a liver-specific immune and stromal microenvironment, yet the natural killer (NK)-cell adaptations associated with this metastatic niche remain incompletely defined.MethodsWe integrate…
Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) haploinsufficiency with autoimmune infiltration (CHAI) is an autosomal dominant condition featuring both immunodeficiency and autoimmunity. We describe the first published mainland Chinese patient har…
Metastatic recurrence is still a major problem for triple-negative breast cancer (TNBC). Neutrophil extracellular traps (NETs) in the pulmonary microenvironment are known to play key roles in the metastatic colonization and outgrowth of TNBC. However, …
ObjectiveTo compare the efficacy and safety of telitacicept as add-on therapy versus standard of care (SOC) alone in immunosuppressant (IS)-naïve patients with lupus nephritis (LN) and in patients with refractory LN.MethodsIn this bicentric, real-world…
X-ray repair cross-complementing protein 1 (XRCC1) is a scaffold protein that functions as a molecular hub, serving as a platform for the recruitment and interaction of multiple DNA repair proteins to coordinate and facilitate multistep DNA repair proc…
Food-specific immunoglobulin G (IgG) have drawn increasing attention in pediatric food intolerance study, yet population-based data and their associations with clinical symptoms remain limited. This retrospective study included 100 children (56 males, …
IntroductionΔ9-Tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, has been reported to modulate immune responses; however, its effects on complex innate immune signaling pathways and inflammation remain incompletely understood….
