ObjectivesThis study aims to identify novel small-molecule inhibitors that target both PD-L1 and EZH2 to enhance colorectal cancer immunotherapy.MethodsA combination of computer-aided molecular simulation, homogeneous time-resolved fluorescence (HTRF) …
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease primarily affecting the intrahepatic small bile ducts. Although PBC is mainly a hepatobiliary disease, renal abnormalities have been reported in a subset of patients an…
The abscopal effect, defined as the regression of non-irradiated tumors following localized radiotherapy (RT), represents one of the most intriguing manifestations of systemic antitumor immunity. Although traditionally considered a rare and unpredictab…
ObjectivesPlatelet transfusion refractoriness (PTR) is a common and clinically challenging condition with complex underlying mechanisms. Human leukocyte antigen (HLA) alloimmunization is the principal cause of immune PTR (iPTR), whereas non-HLA antibod…
IntroductionMast cells (MCs) play important roles in allergic reactions and tissue homeostasis; however, their functions in esophageal squamous cell carcinoma (ESCC) remain controversial. Understanding the heterogeneity and functional states of MCs in …
Multiple sclerosis is a chronic immune mediated disease in which current disease modifying therapies reduce inflammatory relapses but incompletely address neurodegeneration and remyelination. Natural flavonoids are pleiotropic polyphenols that can modu…
Intervertebral disc degeneration (IDD), a leading driver of chronic low back pain, has become a major socioeconomic and public health burden due to its high disability rate and substantial treatment costs. Accumulating evidence has redefined IDD as an …
ObjectiveTo analyze and summarize the general patterns and key points of treatment for cytokine release syndrome (CRS) induced by immune checkpoint inhibitors (ICIs), and provide references for the differential diagnosis and treatment of this immune-re…
J Immunol. 2026 Jul 10;215(7):vkag202. doi: 10.1093/jimmun/vkag202. ABSTRACT Effector gene expression in CD8+ T cells is tightly controlled at the epigenetic and transcriptional levels; however, crucial regulatory signals remain incompletely understood. In this study, we identify dual specificity phosphatase 2 (DUSP2) as a key epigenetic modulator of effector CD8+ T-cell state, by elucidating inhibition of … Read more
J Immunol. 2026 Jul 10;215(7):vkag204. doi: 10.1093/jimmun/vkag204. ABSTRACT Natural killer (NK) cells are cytotoxic innate lymphoid cells that play a critical role in tumor surveillance by releasing proinflammatory cytokines and cytotoxic granules. NKp44 is an activating receptor that promotes NK cell secretion of TNF and IFN-γ upon engaging platelet-derived growth factor D (PDGF-DD), a ligand … Read more
