Publicaciones
The impact of <i>Plasmodium</i>-driven immunoregulatory networks on immunity to malaria
Nature Reviews Immunology, Published online: 11 June 2024; doi:10.1038/s41577-024-01041-5Malaria remains a devastating human disease. Although malaria vaccines are available, their limited efficacy and protective duration are problemat…
Heart failure affects innate immune memory
Nature Reviews Immunology, Published online: 11 June 2024; doi:10.1038/s41577-024-01054-0A study by Nakayama et al. shows that heart failure causes epigenetic changes in haematopoietic stem cells that predispose to further heart diseas…
Engineered γδ T cells show promise in bone tumours
Nature Reviews Immunology, Published online: 11 June 2024; doi:10.1038/s41577-024-01056-yAn adoptive cellular therapy based on γδ T cells, which were engineered to secrete a tumour-targeting opsonin as well as an IL-15 superagonist, co…
Neoadjuvant toripalimab combined with axitinib in patients with locally advanced clear cell renal cell carcinoma: a single-arm, phase II trial
Background
A combination of axitinib and immune checkpoint inhibitors (ICIs) demonstrated promising efficacy in the treatment of advanced renal cell carcinoma (RCC). This study aims to prospectively evaluate the safety, efficacy, and biomarkers of neo…
Poking holes in the blood-brain barrier
Bacterial lipopolysaccharide (LPS) is implicated in disrupting the blood-brain barrier (BBB). In a recent issue of Nature, Wei et al. now show that LPS activates the inflammatory caspases (4, 5, and 11) and gasdermin D (GSDMD) in brain endothelial cell…
Mast cells: The Janus of type 2 inflammation
Mast cells (MCs) are effectors in type 2 immunity, well known for their detrimental roles in allergy. In this issue of Immunity, Alhallak et al. now identify a protective role of MCs against exacerbated immune responses mediated by prostaglandin E2 (PG…
Challenges and opportunities in long COVID research
Long COVID (LC) has become a major public health concern, necessitating multi-pronged research efforts to understand the pathophysiologic mechanisms of this condition and aid in patient diagnosis and treatment. In this perspective, Hamlin and Blish rev…
Not so aDAMant after all: Plasticity of phagocytic microglia
Phagocytic microglia such as proliferative region-associated microglia and disease-associated microglia appear in the brain transiently during development and across various brain pathologies, but their function and degree of plasticity remain unclear….
Claudin 18 turns up the heat in cancer
A major barrier to antitumor immunity in solid tumors is T cell exclusion. In this issue of Immunity, De Sanctis et al. elucidate how CLDN18 on pancreatic and lung cancer cells enhances infiltration, immunological synapse formation, and activation of c…