Bispecific antibodies targeting two inflammatory pathways are entering respiratory medicine at an unprecedented pace. TSLP/IL-13 bispecifics have progressed into mid-to-late-stage clinical development, with two distinct molecules (lunsekimig and CM512)…
Macrophages are important immune cells for cardiac development, homeostasis, and the response to pathological injury and inflammation. Single-cell sequencing and fate-mapping technologies have revealed the heterogeneity and development of cardiac macro…
ObjectiveThis study investigated whether adipose-derived mesenchymal stem cells-exosomes (ADMSC-Exo) alleviate lipopolysaccharide (LPS)-induced acute lung injury (ALI) by regulating NLRP3 inflammasome-mediated macrophage M1 polarization and pyroptosis …
Helicobacter pylori (H. pylori) is a major human pathogen that colonizes the gastric mucosa and is a principal etiological agent of gastritis, peptic ulcer disease, and gastric cancer. Although antibiotic-based eradication regimens are available, their…
ObjectiveTo investigate the dynamic changes of five major peripheral blood immune cell lineages during acute scrub typhus in children and their association with disease severity.MethodsA total of 141 children with clinically diagnosed scrub typhus were…
Available seasonal influenza vaccines, most of which are still produced in eggs, have several limitations. Messenger RNA (mRNA) technology has emerged as a transformative approach capable of overcoming some of these shortcomings. This overview synthesi…
Progression in early Parkinson’s disease (PD) is heterogeneous, motivating transparent biological markers of group-level progression context. We analyzed longitudinal Parkinson’s Progression Markers Initiative (PPMI) data downloaded on 31 May 2026. The…
Food allergy is an immune-mediated condition associated with acute reactions, risk of anaphylaxis, and a substantial day-to-day management burden. Oral immunotherapy (OIT) can increase the amount of allergen tolerated during treatment, but this desensi…
BackgroundHemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome associated with high mortality. Although international recommendations largely guide clinical practice in the Gulf Cooperation Council (GCC) regio…
Immunotherapy has improved outcomes for patients with esophageal squamous cell carcinoma (ESCC), yet a substantial proportion develop resistance. The tumor microenvironment (TME) drives this resistance through four hallmarks: physical barriers formed b…
