BackgroundAging drives metabolic decline and the accumulation of senescent cells that evade immune clearance. The mechanisms linking host-microbiome co-metabolism to peripheral tissue deterioration remain unclear. We hypothesized that age-dysregulated …
Osteoarthritis (OA) is a complex degenerative disease centered on inflammation and involving multi−cellular cooperation, with a continuously rising global burden. Current therapeutic measures mainly focus on symptom relief, slowing progression, and end…
Immunotherapy has redefined oncology, yet its efficacy remains constrained by low response rates, primary or acquired resistance, immune-related toxicities, and escalating costs. Bacteria-mediated cancer immunotherapy (BCIT), which exploits the intratu…
BackgroundIn landscapes where wildlife and livestock co-graze, hosts are often poly-parasitised with diverse nematode and protozoan communities. The relationships between chronic, endemic parasite infections and host immune response is still unknown in…
The global prevalence of allergic rhinitis (AR) continues to rise, imposing a substantial burden on patient quality of life. Its pathogenesis is highly complex, encompassing immune dysregulation, compromised nasal mucosal epithelial barrier function, a…
BackgroundPrevious studies have shown that locoregional therapy combined with systemic treatment provides survival benefits with manageable safety in patients with intermediate-to-advanced large hepatocellular carcinoma (HCC). However, the optimal trea…
IntroductionMaternally transferred immunity plays a critical role in protecting infants from pathogens during the vulnerable period before their own immune system matures. Maternal IgG antibodies cross the placenta and circulate in the infant’s body fo…
PurposeThe study aimed to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) combined with immunotherapy and targeted therapy (IT) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) classification…
