BackgroundHypophosphatasia (HPP) is a rare metabolic disorder caused by mutations in the ALPL gene leading to tissue-nonspecific alkaline phosphatase (TNSALP) deficiency. Although traditionally considered a skeletal disease, emerging evidence suggests …
Breast cancer management still depends on early detection, risk assessment, and individualized treatment. Imaging is used throughout screening, diagnosis, treatment evaluation, and follow-up. For this reason, artificial intelligence (AI) has become an …
Tolerogenic dendritic cells (tolDCs) are a promising cell therapy platform for restoring immune tolerance, but their clinical efficacy is limited by poor phenotypic stability and short in vivo persistence following transfer. Here, we developed biodegra…
BackgroundCrescentic immunoglobulin A nephropathy (IgAN) with Oxford C2 lesions (≥25% crescents) represents a severe disease phenotype. Individual complement markers show inconsistent prognostic value. We developed a composite Complement Activation Ind…
BackgroundAntinuclear antibodies (ANA) are detected in cancer patients before ICI therapy, but their association with immune-related adverse events (irAEs) and outcomes is uncertain. This study aimed to characterize irAEs and tolerability in ANA-positi…
ObjectiveTo delineate the clinical characteristics, diagnostic criteria, therapeutic strategies, and prognosis of myasthenia gravis (MG) with thymoma-associated CRMP5/CV2 antibody-positive paraneoplastic neurological syndrome (PNS), thereby enhancing c…
Despite growing interest in bat–virus interactions, experimental infection studies (EIS) remain taxonomically and geographically restricted, limiting inference about bat immunology and zoonotic risk. We performed a systematic literature search (Jan 190…
IntroductionWhile microRNA (miR) expression profiling has identified potential biomarkers in patients with COVID-19, the regulatory mechanisms by which miRs modulate disease severity remain poorly characterized. We performed integrated miR–proteome ana…
ObjectiveTo examine the associations of nasal microbiota with disease-modifying therapies (DMTs), lymphocyte subsets and olfactory function in multiple sclerosis (MS).MethodsThirty patients with MS and 30 age- and sex-matched healthy controls (HCs) wer…
