IntroductionMaternally transferred immunity plays a critical role in protecting infants from pathogens during the vulnerable period before their own immune system matures. Maternal IgG antibodies cross the placenta and circulate in the infant’s body fo…
PurposeThe study aimed to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) combined with immunotherapy and targeted therapy (IT) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) classification…
TREM2 is a cell surface receptor that plays a crucial role in regulating immune responses, particularly in myeloid cells such as macrophages, dendritic cells, and microglia. Initially studied for its involvement in neuroinflammation and neurodegenerati…
BackgroundIgG4-related disease (IgG4-RD) is a systemic immune-mediated fibrosing inflammatory disorder with multi-organ involvement. Due to highly variable and nonspecific clinical manifestations, atypical cases are prone to misdiagnosis and missed dia…
IntroductionGermline predisposition gene mutations may influence outcomes in patients undergoing hematopoietic stem cell transplantation (HSCT).MethodsThis retrospective study of 558 patients undergoing HSCT (allo-HSCT in 557 cases, auto-HSCT in 1 case…
BackgroundTriple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by significant inter- and intra-tumoral heterogeneity. Its varied response to radiotherapy limits clinical outcomes, yet the underlying molecular determinants r…
BackgroundSepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Its immunopathology is characterized by a dynamic imbalance between pro-inflammatory and anti-inflammatory responses. Interferon-γ (IFN-γ) and…
The therapeutic landscape for advanced non-small cell lung cancer (NSCLC) has been transformed by immune checkpoint inhibitors (ICIs), yet significant response heterogeneity necessitates robust, dynamic predictive biomarkers. Conventional tissue-based …
Radiation-induced oral mucositis (RIOM) is one of the most common and severe complications in patients with head and neck malignancies undergoing radiotherapy or chemoradiotherapy, with an incidence of 80–100%. More than half of patients develop severe…
BackgroundSevere cutaneous ulceration in antiphospholipid syndrome (APS) with concurrent infection and thrombocytopenia presents a therapeutic dilemma: standard immunosuppression risks worsening infection, while anticoagulation risks hemorrhage. We pre…
