Publicaciones

Allogeneic hematopoietic stem cell transplantation is associated with improved survival compared with chemotherapy in patients with acute myeloid leukemia harboring favorable-risk genetic features at initial diagnosis: a single-center retrospective study

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BackgroundAcute myeloid leukemia (AML) harboring favorable-risk genetic features at initial diagnosis (FR-AML) commonly achieves remission after chemotherapy, but the optimal post-remission strategy remains controversial. This study compared allogeneic…

Case Report: Severe mixed autoimmune hemolytic anemia associated with acute cytomegalovirus infection in an immunocompetent adult

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BackgroundCytomegalovirus (CMV)-associated hemolytic anemia (HA) is rare in immunocompetent hosts and may present with heterogeneous serologic phenotypes, including direct antiglobulin test (DAT)-negative hemolysis, warm autoimmune hemolytic anemia (AI…

Treponema pallidum suppressive microenvironments and central nervous system damage: from mechanisms to tools and prevention

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The global resurgence of syphilis, marked by a dramatic 150% increase in cases over the last decade and the rise of the dominant SS14-Ω strain cluster, represents a critical threat to public health. This review explores the complex molecular mechanisms…

Clinical improvement of pemphigus-like mucocutaneous disease in a patient with CLL following initiation of zanubrutinib: a case report

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Pemphigus is an autoimmune bullous disease. PNP/PAMS represents a rare subtype of autoimmune bullous disease, and typically associated with an underlying neoplasm, particularly lymphoproliferative disorders. Current management of PNP primarily involves…

Pediatric ectodermal dysplasia with immunodeficiency caused by a hemizygous IKBKG frameshift variant: a case report and literature review

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ObjectiveThis case report looks at a child’s ectodermal dysplasia with immunodeficiency (EDA-ID), caused by a mutation in the IKBKG gene, and other relevant cases.MethodsA pediatric patient diagnosed with EDA-ID was examined at Shanxi Bethune Hospital …

ASNS-dependent asparagine availability supports intestinal ILC2 responses and type 2 immunity under nutrient-limited conditions

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IntroductionNutrient availability critically governs group 2 innate lymphoid cell (ILC2) function and type 2 immunity. Here, we identify the non-essential amino acid asparagine (Asn) as a critical metabolite required for ILC2 survival and function.Meth…

Targeting the remodeled peritoneal ecosystem: a paradigm shift from tumor cells to the microenvironment in gastric cancer peritoneal metastasis

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Peritoneal metastasis (PM) is the most common form of organ-specific metastasis in advanced gastric cancer (GC), and is driven by the dynamic interplay between cancer cells and the tumor microenvironment (TME). This review elaborates on the mechanisms …

Multidimensional neuropsychological heterogeneity in obstructive sleep apnea: deep clinical phenotyping in a single-center cohort, population proteomic context, and depressive-burden risk stratification

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BackgroundObstructive sleep apnea (OSA) is associated with substantial cognitive and affective burden, yet conventional respiratory severity does not fully explain this heterogeneity. We investigated whether neuropsychological vulnerability in OSA show…

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