Tumor immune escape is not determined solely by immune checkpoints, suppressive cytokines, or changes in immune-cell composition; it is also organized by the metabolic architecture of the tumor microenvironment. Reprogrammed amino acid metabolism contr…
BackgroundThe addition of immunotherapy to definitive chemoradiotherapy has improved outcomes for patients with unresectable advanced esophageal squamous-cell carcinoma (ESCC). However, treatment-related hematologic toxicity, particularly radiation-ind…
BackgroundImmunotherapy has emerged as a breakthrough in cancer treatment; however, the functional status of B lineage cells within the tumor microenvironment (TME) remains poorly characterized.ObjectiveThis study systematically profiles the heterogene…
Osteosarcoma is an aggressive malignancy characterized by inherent chemoresistance, a high propensity for pulmonary metastasis, and dismal survival rates in patients with advanced or refractory disease. While immunotherapy has revolutionized cancer tre…
Immune checkpoint inhibitors have significantly improved therapeutic outcomes in advanced melanoma; however, their clinical efficacy is greatly limited by low overall response rates and the primary or acquired resistance. Here, we developed a SpyCatche…
Lysophosphatidylcholines (LPCs) are among the most abundant circulating bioactive lipids, whose fatty acid compositions critically influence their immunomodulatory functions. Alterations in circulating LPC species have been implicated in inflammatory s…
BackgroundHenoch-Schönlein purpura nephritis (HSPN) is a common secondary glomerular disease in children. Approximately 30% of children with Henoch-Schönlein purpura develop this renal complication, and among them, about 20% may progress to chronic kid…
MOGAD is a rare autoimmune encephalomyelitis that shares similar clinical manifestations with other central nervous system demyelinating diseases. However, they must be distinguished due to their distinct pathogenesis and treatment methods. Currently, …
IntroductionCognitive impairment significantly impacts social function in Bipolar disorder (BD). This study explores the link between immune markers, white matter microstructure, and cognitive function in depressed BD patients enhance early diagnosis a…
