Publicaciones

T cell immunity to SARS-CoV-2 vaccination in inflammatory bowel disease patients treated with anti-cytokine biologics

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J Immunol. 2026 Jul 10;215(7):vkag173. doi: 10.1093/jimmun/vkag173. ABSTRACT Anti-TNF and anti-IL-12/IL-23 are commonly used therapies for immune-mediated inflammatory diseases (IMIDs), including inflammatory bowel disease (IBD). Although several studies have shown intact T cell responses following 2 to 3 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in biologics treated IMID patients, our group … Read more

Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice

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J Immunol. 2026 Jul 10;215(7):vkag205. doi: 10.1093/jimmun/vkag205. ABSTRACT Our laboratory has previously described a mouse model (CD40LΔ5) that produces 60% of wild-type CD40L due to a targeted deletion in an RNA binding site within the CD40L message. The CD40LΔ5 mutation, which destabilizes CD40L mRNA during T-cell activation, causes disrupted germinal center (GC) formation, leading to … Read more

Myosin VI drives breast cancer progression via SP1/CA9-mediated acidic tumor microenvironment remodeling and subsequent M2 macrophage polarization

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Background
The acidic tumor microenvironment (TME) is a major driver of immunosuppression and tumor progression in breast cancer. Although myosin VI (MYO6), an actin-dependent motor protein, is frequently upregulated in malignancies, its function in i…

Combined circulating tumor antigen model demonstrates additional prognostic value in first-line treatment of non-small cell lung cancer

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Background
Circulating tumor antigens (ctA; tumor markers) are blood-based proteins that can offer prognostic value in non-small cell lung cancer (NSCLC) and may serve as potential early surrogates for survival. Given the significantly reduced testing…

Cancer-associated mesothelial cells drive immune escape and therapy resistance in ovarian cancer

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Background
Cancer-associated mesothelial cells (CAMCs) are key modulators of the ovarian tumor microenvironment, contributing to tumor growth and immune evasion. Mesothelial cells (MCs) maintain peritoneal homeostasis and immune surveillance and repre…

The Respiratory Epithelial Barrier as an Immunopharmacological Rheostat: From Homeostatic Sentinel to Therapeutic Target in Chronic Lung Disease. [[{“value”:”Feng‐Xian Ni, Jie Hu, Hui‐Hui Chen, Dong‐Hui Huang, Ze‐Bo Jiang”}]]

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This review introduces the “Epithelial Immunopharmacological Rheostat,” a framework where the respiratory epithelium calibrates immune tolerance versus inflammation through four interacting axes. Dysregulation of these axes drives chronic lung diseases, offering a roadmap for precision therapies that reset the rheostat. ABSTRACT The respiratory epithelium is a dynamic immunopharmacological interface that transcends its traditional role as … Read more

Engineering Soluble Recombinant BCMA for Ide‐Cel Labeling. [[{“value”:”Ly Phuong Vy Nguyen, Christelle Oblet, Alice Barbarin, Louis Waeckel, Farah Kotaich, Clara Petit, Marine Mabily, Claire Carrion, André Herbelin, Jean Marc Gombert, Xavier Leleu, Emilie Chalayer, Murielle Roussel, Patrick Legembre”}]]

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This study describes the generation of a recombinant IFNα2-BCMAext-GFP probe, which enables sensitive detection of BCMA-directed CAR-T cells. The probe efficiently identifies idecabtagene vicleucel (ide-cel) CAR-T cells in patients with multiple myeloma and provides a simple alternative to current BCMA-based detection reagents. ABSTRACT Chimeric antigen receptor (CAR)-T-based strategies target the B-cell maturation antigen (BCMA) expressed … Read more

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